EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.270 | 17beta-hydroxy-5alpha-androstan-3-one + NADPH |
DHT |
Mus musculus |
5alpha-androstane-3beta,17beta-diol + NADP+ |
androstanediol |
? |
1.1.1.270 | 17beta-hydroxy-5alpha-androstan-3-one + NADPH |
DHT |
Rattus norvegicus |
5alpha-androstane-3beta,17beta-diol + NADP+ |
androstanediol |
ir |
1.1.1.270 | 17beta-hydroxy-5alpha-androstan-3-one + NADPH |
DHT |
Mus musculus |
5alpha-androstane-3beta,17beta-diol + NADP+ |
5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol |
? |
1.1.1.270 | 17beta-hydroxy-5alpha-androstan-3-one + NADPH |
DHT |
Rattus norvegicus |
5alpha-androstane-3beta,17beta-diol + NADP+ |
corresponding 3beta-hydroxysteroid |
ir |
1.1.1.270 | 17beta-hydroxy-5alpha-androstan-3-one + NADPH |
dihydrotestosterone |
Mus musculus |
5alpha-androstane-3beta,17beta-diol + NADP+ |
androstanediol |
? |
1.1.1.270 | 17beta-hydroxy-5alpha-androstan-3-one + NADPH |
dihydrotestosterone |
Rattus norvegicus |
5alpha-androstane-3beta,17beta-diol + NADP+ |
androstanediol |
ir |
1.1.1.270 | 17beta-hydroxy-5alpha-androstan-3-one + NADPH |
dihydrotestosterone |
Mus musculus |
5alpha-androstane-3beta,17beta-diol + NADP+ |
5alpha-androstane-3alpha,17beta-diol or 5alpha-androstane-3beta,17beta-diol |
? |
1.1.1.270 | 17beta-hydroxy-5alpha-androstan-3-one + NADPH |
dihydrotestosterone |
Rattus norvegicus |
5alpha-androstane-3beta,17beta-diol + NADP+ |
corresponding 3beta-hydroxysteroid |
ir |
1.1.1.270 | 2 17beta-hydroxy-5alpha-androstan-3-one + 2 NADPH + 2 H+ |
- |
Homo sapiens |
5alpha-androstane-3beta,17beta-diol + 5alpha-androstane-3alpha,17beta-diol + 2 NADP+ |
the rates of 3alpha-diol versus 3beta-diol formation varies significantly among the isoforms. AKR1C1 predominantly catalyzes the formation of 3beta-diol, whereas AKR1C2 and AKR1C4 predominantly catalyze the formation of 3alpha-diol. AKR1C3 shows relatively low reductive activity towards 17beta-hydroxy-5alpha-androstan-3-one, in which 3alpha-diol and 3beta-diol is formed in almost equal amounts |
? |
1.1.1.270 | 2 17beta-hydroxy-5alpha-androstan-3-one + 2 NADPH + 2 H+ |
AKR1cs are a source of beta-tetrahydrosteroids. This is of physiological significance because the formation of 3beta-diol in contrast to 3alpha-diol is virtually irreversible, the 3beta-diol is a pro-apoptotic ligand for estrogen receptor beta, and 3beta-tetrahydrosteroids act as gamma-aminobutyric acid type A receptor antagonists |
Homo sapiens |
5alpha-androstane-3beta,17beta-diol + 5alpha-androstane-3alpha,17beta-diol + 2 NADP+ |
- |
? |