EC Number   |
Substrates   |
Products   |
Reversibility   |
|---|
 3.4.24.B11 | thrombospondin-2 + H2O |
- |
42000 Da fragment + 30000 Da fragment |
- |
? |
 3.4.24.B11 | tissue factor pathway inhibitor-2 + H2O |
- |
? |
- |
? |
 3.4.24.B11 | Type I collagen + H2O |
- |
? |
- |
? |
 3.4.24.B11 | versican + H2O |
- |
? |
- |
? |
 3.4.24.B11 | versican + H2O |
chondroitin sulphate proteoglycan-2 |
? |
- |
? |
 3.4.24.B11 | versican + H2O |
versican proteolysis in cardiac jelly at the canonical Glu441-Ala442 site is cooperatively mediated by ADAMTS1 and ADAMTS5 and required for proper ventricular cardiomyogenesis |
? |
- |
? |
 3.4.24.B11 | versican + H2O |
ADAMTS1 versicanase activity is approximately 1000fold lower than ADAMTS5 and 50fold lower than ADAMTS4 |
? |
- |
? |
 3.4.24.B11 | versican + H2O |
ADAMTS-1 cleaves versican at the Glu441-Ala442 bond to generate a 70000 Da fragment termed DPEAAE |
DPEAAE + ? |
- |
? |
 3.4.24.B11 | versican isoform V0 + H2O |
a second cleavage site might be Glu405-Gln406, cleavage site is Glu1428-Ala1429 in the V0 isoform, activity with recombinant and native human substrate protein |
2 peptides |
product identification |
? |
 3.4.24.B11 | versican isoform V1 + H2O |
a second cleavage site might be Glu405-Gln406, cleavage site is Glu441-Ala442 in the V1 isoform, activity with recombinant and native human substrate protein |
2 peptides |
product identification |
? |