EC Number   |
Substrates   |
Products   |
Reversibility   |
|---|
 3.4.24.B11 | brevican + H2O |
assay at 37°C, 3 h, 25 nM recombinant ADAMTS |
? |
- |
? |
 3.4.24.B11 | Collagen type I + H2O |
- |
? |
- |
? |
 3.4.24.B11 | desmocollin-3 + H2O |
- |
? |
- |
? |
 3.4.24.B11 | dystroglycan 1 + H2O |
- |
? |
- |
? |
 3.4.24.B11 | fluorescein-5(6)-carbonyl-Ala-Glu-Leu-Asn-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lys + H2O |
- |
? |
- |
? |
 3.4.24.B11 | Mac-2-binding protein + H2O |
- |
? |
- |
? |
 3.4.24.B11 | more |
enzyme inhibits fibroblast growth factor 2-induced vascularization in the cornea pocket assay and inhibits vascular endothelial growth factor-induced angiogenesis in the chorioallantoic membrane assay |
? |
- |
? |
 3.4.24.B11 | more |
no activity with pro-collagen type I and III, collagen types I, II, IV, V, VIII and XVIII, fibronectin, laminin, vibronectin, and thrombospondin 1 |
? |
- |
? |
 3.4.24.B11 | more |
vascular endothelial growth factor 165 and vascular endothelial growth factor 165 receptor tyrosine kinase are no substrates for proteolytic cleavage, but the enzyme blocks endothelial vascularization by inhibiting the necessary phosphorylation of the receptor |
? |
- |
? |
 3.4.24.B11 | more |
enzyme has anti-aniogenic properties, processed form p65 shows altered affinity to heparin and endothelial cells, reduced activity upon suppression of endothelial cell proliferation |
? |
- |
? |