EC Number   |
Substrates |
Products |
Reversibility |
|---|
   3.4.21.108 | X-linked inhibitor of apoptosis protein + H2O |
- |
? |
- |
? |
| 3.4.21.108 | X-linked inhibitor of apoptosis protein + H2O |
BIR2 |
? |
- |
? |
| 3.4.21.108 | X-linked inhibitor of apoptosis protein + H2O |
autocatalytically processing of HtrA2 to the 36-kDa protein fragment, which is required for the cytochrome c-dependent caspase activation, promoting apoptotic cell death |
? |
- |
? |
| 3.4.21.108 | X-linked inhibitor of apoptosis protein + H2O |
C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity |
? |
- |
? |
| 3.4.21.108 | X-linked inhibitor of apoptosis protein + H2O |
homotrimeric structure of enzyme is required for executing its activity |
? |
- |
? |
| 3.4.21.108 | X-linked inhibitor of apoptosis protein + H2O |
Omi/HtrA2 cleaves as well as directly binds and inactivates X-linked inhibitor of apoptosis protein to promote caspase activation |
? |
- |
? |
