EC Number   |
Substrates |
Products |
Reversibility |
|---|
   3.4.21.108 | 35S-beta-casein + H2O |
C-terminus of presenilin-1 interacts the PDZ domain of with Omi/HtrA2, increasing its activity |
? |
- |
? |
| 3.4.21.108 | A beta 40 |
HtrA2/Omi binds preferentially to the short form of A beta peptides, the enzyme does not perform degradation by direct hydrolysis |
? |
- |
? |
| 3.4.21.108 | A beta 42 |
HtrA2/Omi binds poorly to A beta 42, the enzyme does not perform degradation by direct hydrolysis |
? |
- |
? |
| 3.4.21.108 | Ala(7-methoxycoumarin-4-acetic acid)-IRRVSYSF-(5-amido-2-nitrobenzamide) + H2O |
- |
? |
- |
? |
| 3.4.21.108 | alpha-casein + H2O |
- |
? |
- |
? |
| 3.4.21.108 | alpha-secretase peptide |
HtrA2/Omi does not perform degradation by direct hydrolysis |
? |
- |
? |
| 3.4.21.108 | amyloid precursor protein + H2O |
- |
? |
- |
? |
| 3.4.21.108 | amyloid precursor protein + H2O |
efficient cleavage by HtrA2 in the normal physiological condition. HtrA2-mediated cleavage product is the C161 fragment encompassing amino acids 535695 of amyloid precursor protein 695. Mature HtrA2 and full-length HtrA2 can process amyloid precursor protein into C161 |
? |
- |
? |
| 3.4.21.108 | amyloid precursor protein + H2O |
APP |
? |
- |
? |
| 3.4.21.108 | amyloid precursor protein-like protein 1 + H2O |
processed into two major fragments of 65 and 67 kDa |
? |
- |
? |
