EC Number   |
Substrates  |
Products |
Reversibility |
|---|
    2.7.6.2 | UTP + thiamine |
- |
UMP + thiamine diphosphate |
- |
? |
| 2.7.6.2 | UTP + thiamine |
207% of the activity with ATP |
UMP + thiamine diphosphate |
- |
? |
| 2.7.6.2 | thiamine + ATP |
- |
thiamine diphosphate + AMP |
- |
? |
| 2.7.6.2 | thiamine + ATP |
TPP plays a critical role in the carbohydrate and energy metabolism. It functions as a prosthetic group for the mitochondrial enzyme complexes like pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and branched chain alpha-keto acid dehydrogenase. In addition, TPP is involved in the cytosolic pentose pathway functioning as coenzyme for transketolase. |
thiamine diphosphate + AMP |
- |
? |
| 2.7.6.2 | thiamin + ATP |
- |
thiamindiphosphate + AMP |
- |
? |
| 2.7.6.2 | pyrithiamine + ATP |
its specific activity is 30% lower in comparison to its natural substrate thiamine |
pyrithiamine diphosphate + AMP |
- |
? |
| 2.7.6.2 | pyrithiamine + ATP |
inhibits the substrate thiamine |
pyrithiamine diphosphate + AMP |
- |
? |
| 2.7.6.2 | oxythiamine + ATP |
- |
oxythiamine diphosphate + AMP |
- |
? |
| 2.7.6.2 | more |
three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight, overview |
? |
- |
? |
| 2.7.6.2 | more |
the YcfN protein acts as a nonspecific adenosylcobinamide kinase enzyme, which is not associated with adenosylcobalamine biosynthesis, but it allows a CobU-deficient strain of serovar Typhimurium to synthesize enough adenosylcobalamine from cobinamide so that the cell can grow. YcfN is required for the phosphorylation of thiamine in the thiamine salvaging pathway of Escherichia coli |
? |
- |
? |
