EC Number   |
Substrates   |
Products   |
Reversibility   |
|---|
  2.1.1.355 | more |
histone methylation has significant effects on heterochromatin formation and transcriptional regulation |
? |
- |
? |
  2.1.1.355 | more |
growth factor independent 1 and G9a complex methylates the wild-type H3 substrate as well as the mutants replaced at K4, K36, and K79, substitution at K27 slightly reduces methylation of the H3 substrate, whereas substitution at K9 blocks methylation |
? |
- |
? |
  2.1.1.355 | more |
minimal substrate methylated by G9a contains seven amino acids (TARKSTG) of the histone H3 tail |
? |
- |
? |
  2.1.1.355 | more |
the NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance |
? |
- |
? |
  2.1.1.355 | more |
no activity is observed on trimethylated histone H3(K9) peptides either with or without ubiquitin |
? |
- |
? |
  2.1.1.355 | more |
the enzyme is automethylated at K239 |
? |
- |
? |
  2.1.1.355 | more |
the enzyme is able to add methyl groups to lysine 27 as well as 9 in histone H3 |
? |
- |
? |
  2.1.1.355 | more |
SETDB1 specifically methylates H3K9, but not H3K4 or H3K27. SETDB1 methylates H3 to generate K9me1, K9me2, and K9me3 in a sequential manner |
? |
- |
? |
  2.1.1.355 | more |
Clr4 automethylates lysines K455 and K472 |
? |
- |
- |
  2.1.1.355 | more |
SUV39H2 also trimethylates LSD1 at K322. SUV39H2 also methylates K134 of H2AX |
? |
- |
- |