EC Number   |
Specific Activity Minimum [µmol/min/mg] |
Specific Activity Maximum [µmol/min/mg] |
Reference |
|---|
   3.4.22.40 | -999 |
- |
all analyzed mutants compromised in catalytic activity, replacement of the active-site asparagine with alanine, valine or leucine results in destabilization of the histidine side chain and the role of the asparagine residue in correctly positioning the histidine for catalysis, replacement of the histidine with alanine or leucine destabilizes asparagine position |
683132 |
| 3.4.22.40 | -999 |
- |
bleomycin hydrolase-deficient mice unimpaired in epitope presentation from N-extended precursors or whole antigens, expression of normal levels of MHC class I molecules observed, in vivo CD8 T cell responses to eight epitopes from three different viruses unaffected, redundancy with other aminopeptidases in predicted role on antigen presentation determined |
683736 |
| 3.4.22.40 | -999 |
- |
detection of bleomycin hydrolase by ELISA, Western blot, immunohistochemistry and immunoelectron microscopic, present in the range between 3.7 and 131.1 ng per mg of rat tissues |
683613 |
| 3.4.22.40 | -999 |
- |
detection of bleomycin hydrolase by ELISA, Western blot, immunohistochemistry and immunoelectron microscopic, present in the range between 3.7 and 131.1 ng per mg of rat tissues, increased at 6 weeks after birth, then slightly decreased |
683613 |
| 3.4.22.40 | -999 |
- |
response to chemotherapy dependent on gene polymorphism of bleomycin hydrolase analyzed, homozygous variant G/G of bleomycin hydrolase gene SNP A1450G associated with reduced survival and higher prevalence of early relapses in testicular germ-cell cancer patients treated with bleomycin-containing chemotherapy |
683707 |
| 3.4.22.40 | -999 |
- |
role of bleomycin protease in the brain analyzed, behavioral phenotype of knockout mice studied using multiple behavioral paradigms, physiological non-redundant function for bleomycin hydrolase in the CNS suggested |
683931 |
| 3.4.22.40 | 1.09 |
- |
- |
36724 |
| 3.4.22.40 | 189 |
- |
pH 5.2, 30°C |
649347 |
| 3.4.22.40 | 815 |
- |
- |
36719 |
