EC Number   |
Specific Activity Minimum [µmol/min/mg] |
Specific Activity Maximum [µmol/min/mg] |
Reference |
|---|
   3.1.3.67 | -999 |
- |
- |
25140 |
| 3.1.3.67 | -999 |
- |
activity of PTEN is dependent on extent of membrane binding, phosphorylation of the C-terminal cluster has an inhibitory effect on membrane association and activity |
694916 |
| 3.1.3.67 | -999 |
- |
alanine substituted PTEN is 7fold more active than wildtype PTEN |
694916 |
| 3.1.3.67 | -999 |
- |
carbonylation of PTEN increases significantly in ethanol-fed mice compared to pair-fed control animals, corresponding to decreased PTEN3-phosphatase activity |
731861 |
| 3.1.3.67 | -999 |
- |
loss of PTEN activity in knockout mice modell leads to activation of lipogenesis, as evidences from increased mRNA levels for sterol regulatory element binding protein 1c, fatty acid synthase and acetyl-CoA carboxylase |
692556 |
| 3.1.3.67 | -999 |
- |
loss of PTEN activity in the Hep-G2 cell line leads to activation of lipogenesis, as evidenced from increased mRNA levels for sterol regulatory element binding protein 1c, fatty acid synthase and acetyl-CoA carboxylase |
692556 |
| 3.1.3.67 | -999 |
- |
modulation of PTEN influences the microsomal triglyceride transfer protein mass and lipid transfer activity |
692556 |
| 3.1.3.67 | -999 |
- |
protein levels of PTEN in the liver of 13-week-old male mice with PTEN liver-specific knockout are significantly decreased to 16% of that in the control mice |
692556 |
| 3.1.3.67 | -999 |
- |
PTEN cellular activity is proportional to the extent of membrane association |
694916 |
| 3.1.3.67 | -999 |
- |
PTEN is an interfacially activated enzyme. PTEN can exist in 2 active states, one favouring metabolism of soluble substrates and the interfacially activity state is necessary for efficient metabolism of phosphatidylinositol 3,4,5-trisphosphate. |
694495 |
