EC Number   |
Recommended Name |
Source Tissue |
Reference |
|---|
   1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
rostral ventrolateral medulla |
microinjection of lipopolysaccharide bilaterally into the rostral ventrolateral medulla induces progressive hypotension, bradycardia, and reduction in sympathetic vasomotor outflow. This is accompanied by an increase in superoxide anion production for 60-240 min, alongside phosphorylation of subunits p47phox or p67phox, upregulation of gp91phox or p47phox protein, and increase in Rac-1 or NADPH oxidase activity during 60-120 min, and a depression of mitochondrial respiratory enzyme activity during 120-240 min. Inhibition of NADPH oxidase or knockdown of the gp91phox or p47phox gene blunts the early phase of 60-150 min, coenzyme Q10 or mitochondrial KATP channel inhibitor antagonizes the delayed phase of 120-240 min of lipopolysaccharide-nduced increase in superoxide anion production in rostral ventrolateral medulla and cardiovascular depression |
686859 |
| 2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
rostral ventrolateral medulla |
- |
708686 |
| 3.4.17.23 | angiotensin-converting enzyme 2 |
rostral ventrolateral medulla |
- |
680099 |
| 3.4.19.12 | ubiquitinyl hydrolase 1 |
rostral ventrolateral medulla |
de novo synthesis of UCH-L1, leading to an enhanced dissassembly of ubiquitin-protein conjugates in the rostral ventrolateral medulla, is essential to maintenance of the pro-life phase of mevinphos intoxication via prevention of cardiovascular depression, leading to neuroprotection |
666929 |
