EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.1 | alcohol dehydrogenase |
retina |
isozyme ADH4 |
655479 |
1.1.1.105 | all-trans-retinol dehydrogenase (NAD+) |
retina |
- |
-, 285723, 689771, 722769 |
1.1.1.105 | all-trans-retinol dehydrogenase (NAD+) |
retina |
the highest level of RDH12 expression is in the retina where it is localised to the inner segments and cell bodies of rod and cone photoreceptors |
697796 |
1.1.1.205 | IMP dehydrogenase |
retina |
- |
703193, 760826 |
1.1.1.205 | IMP dehydrogenase |
retina |
high expression |
761406 |
1.1.1.205 | IMP dehydrogenase |
retina |
IMPDH1 predominates in the adult retina |
703193 |
1.1.1.205 | IMP dehydrogenase |
retina |
inosine monophosphate dehydrogenase is present in all immature cells throughout the retina during embryonic and neonatal development. Following eye opening and cell differentiation, its distribution is restricted to the photoreceptors and bipolar cell, becoming prominent in Muller cells with ageing. Type I enzyme does not play a role in early retinal development but type Igamma has greater activity after postnatal day 10. All forms of type I show an increased propensity to form intracellular macrostructures compared to type II |
687120 |
1.1.1.205 | IMP dehydrogenase |
retina |
isoform IMPDH1 undergoes alternate splicing to produce at least two retinal isoforms. The abundance of isoforms differs between the species |
689095 |
1.1.1.205 | IMP dehydrogenase |
retina |
retinal-specific isoforms IMPDH1(546) and IMPDH1(595) |
684706 |
1.1.1.21 | aldose reductase |
retina |
- |
286262, 712190, 713240 |
1.1.1.21 | aldose reductase |
retina |
whole retina and ocular tissue cryo sections |
-, 737617 |
1.1.1.211 | long-chain-3-hydroxyacyl-CoA dehydrogenase |
retina |
neural, developing |
670476 |
1.1.1.284 | S-(hydroxymethyl)glutathione dehydrogenase |
retina |
- |
-, 725072 |
1.1.1.300 | NADP-retinol dehydrogenase |
retina |
- |
-, 689771, 712068, 722769, 723236, 740899, 761323, 761488, 762430, 763516 |
1.1.1.300 | NADP-retinol dehydrogenase |
retina |
expression in inner segments, cell bodies and synaptic termini of photoreceptors |
712068 |
1.1.1.300 | NADP-retinol dehydrogenase |
retina |
level of isoform Rdh11 is low and remarkably constant during development and oxidative stress. Rdh12 expression starts at postnatal day 7 and increases until postnatal day 30 to approximately sevenfold higher than Rdh11. Oxidative stress induced by exposure to constant bright light leads to a rapid and significant decrease of Rdh12 protein |
687202 |
1.1.1.300 | NADP-retinol dehydrogenase |
retina |
RDH10 is upregulated in rod/cone hybrid retinas |
762430 |
1.1.1.300 | NADP-retinol dehydrogenase |
retina |
RDH12 expression starts at postnatal day and increases until postnatal day 30. Oxidative stress induced by exposure to constant bright light leads to a rapid and significant decrease of RDH12 protein |
687202 |
1.1.1.300 | NADP-retinol dehydrogenase |
retina |
the RDH11 level is low and remarkably constant during development and oxidative stress |
687202 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
retina |
- |
715451, 762430 |
1.1.1.315 | 11-cis-retinol dehydrogenase |
retina |
pigment epithelium and sclera, low mRNA expression |
692939 |
1.1.1.71 | alcohol dehydrogenase [NAD(P)+] |
retina |
- |
740291 |
1.1.1.87 | homoisocitrate dehydrogenase |
retina |
mRNA expression of isoform Rdh10 both in the prospective pigmented epithelium and neural retina |
687988 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
retina |
- |
394876 |
1.13.11.31 | arachidonate 12-lipoxygenase |
retina |
- |
-, 741976 |
1.13.11.34 | arachidonate 5-lipoxygenase |
retina |
retinal blood vessels of wild-type and mutant mice, diabetic mice show increased expression of leukotriene B4 receptors |
-, 686304 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
retina |
enzyme is highly expressed in retinal pigment epithelium |
438236 |
1.13.11.71 | carotenoid-9',10'-cleaving dioxygenase |
retina |
macular pigment |
-, 746290 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
retina |
constitutive, soluble form |
-, 440232 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
retina |
distribution, overview, in retinorecipient tectal layer, before and after axotomy and fibroblast growth factor-2 application |
672844 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
retina |
- |
689096 |
1.14.14.25 | cholesterol 24-hydroxylase |
retina |
- |
-, 712869, 727298, 735602 |
1.14.14.25 | cholesterol 24-hydroxylase |
retina |
ganglion cells |
687987 |
1.14.14.25 | cholesterol 24-hydroxylase |
retina |
neuronal part |
704109 |
1.14.14.25 | cholesterol 24-hydroxylase |
retina |
quantification of membrane-associated CYP46A1 in brain and retina, and analysis of tissue-dependent enzyme-product relationships, overview |
712869 |
1.14.14.25 | cholesterol 24-hydroxylase |
retina |
specific high expression of CYP46A1 in the neural retina, low expression in the retinal pigment epithelium, no expression in the ciliary body |
686258 |
1.14.14.79 | docosahexaenoic acid omega-hydroxylase |
retina |
- |
728344 |
1.14.15.15 | cholestanetriol 26-monooxygenase |
retina |
- |
725428 |
1.14.16.2 | tyrosine 3-monooxygenase |
retina |
- |
697039 |
1.14.19.17 | sphingolipid 4-desaturase |
retina |
- |
744398 |
1.14.19.17 | sphingolipid 4-desaturase |
retina |
within the neural retina, Des1 is expressed in Müller cells, the site of the proposed alternative visual cycle. Des1 is also expressed in the retinal pigment epithelium, where it may augment synthesis of cis-11-retinol |
744686 |
1.14.19.3 | acyl-CoA 6-desaturase |
retina |
- |
438421 |
1.14.99.66 | [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase |
retina |
the highest expression of LSD1 occurs in postmitotic retinal cells during the peak period of rod photoreceptor differentiation. LSD1 appears to be absent at the outer margin of the retina, enzyme distribution, overview |
745804 |
1.18.1.6 | adrenodoxin-NADP+ reductase |
retina |
- |
718572 |
1.2.1.12 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) |
retina |
- |
743755 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
retina |
- |
691044 |
1.2.1.36 | retinal dehydrogenase |
retina |
- |
692668 |
1.2.1.36 | retinal dehydrogenase |
retina |
photoreceptor inner segments and the outer nuclear layer |
694144 |
1.21.99.3 | thyroxine 5-deiodinase |
retina |
- |
715991 |
1.3.1.48 | 13,14-dehydro-15-oxoprostaglandin 13-reductase |
retina |
retinal pigment epithelium choroid |
390825 |
1.4.1.27 | glycine cleavage system |
retina |
in rat brain, the P-protein is confined to astrocytes. The intensity of astrocyte staining varies with regions, with the strongest staining in the hippocampus, the cerebellar cortex, the Bergmann glia in the cerebellum and the Muller cells in the retina |
758982 |
1.4.1.3 | glutamate dehydrogenase [NAD(P)+] |
retina |
- |
712431 |
1.4.3.1 | D-aspartate oxidase |
retina |
- |
686597, 711719 |
1.4.3.13 | protein-lysine 6-oxidase |
retina |
- |
698383 |
1.4.3.13 | protein-lysine 6-oxidase |
retina |
localization of LOX and LOXL in different tissue areas, LOX is located in the inner surface of the pigmented epithelia in the photoreceptor layer, LOXL is located in the inner nuclear layer within the outer plexiform layer and in the ganglion cells |
659751 |
1.4.3.21 | primary-amine oxidase |
retina |
- |
703130 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
retina |
distribution in bovine cornea and lens |
392117 |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
retina |
much lower levels than in liver, preferentially localized in Müller cells, FDH levels in human retina are higher than in rat retina, folate levels in human retina are 14% of those in rat retina |
392355 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
retina |
- |
684364, 689097, 711688 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
retina |
retinal ganglion cell reactive oxygen species and retinal NAD(P)H oxidase activity are higher in spontaneously hypertensive rats than in wild-type rats |
685865 |
1.6.99.1 | NADPH dehydrogenase |
retina |
from embryo |
392790 |
1.8.1.7 | glutathione-disulfide reductase |
retina |
- |
394723 |
1.8.4.11 | peptide-methionine (S)-S-oxide reductase |
retina |
maximal expression level of MsrA in kidney and liver, followed by heart, lung, brain, skeletal muscle, retina, testis, bone marrow, and blood |
763918 |
1.8.4.11 | peptide-methionine (S)-S-oxide reductase |
retina |
peripheral |
668513 |
1.8.4.11 | peptide-methionine (S)-S-oxide reductase |
retina |
retinal pigment epithelium |
742555 |
1.8.4.12 | peptide-methionine (R)-S-oxide reductase |
retina |
- |
711940 |
1.8.4.12 | peptide-methionine (R)-S-oxide reductase |
retina |
ethionine sulfoxide reductase B2 is highly expressed in the retina, in the monkey retina MSRB2 localizes to the ganglion cell layer, the outer plexiform layer and the retinal pigment epithelium |
711940 |
1.8.4.2 | protein-disulfide reductase (glutathione) |
retina |
- |
394810 |
2.1.1.100 | protein-S-isoprenylcysteine O-methyltransferase |
retina |
- |
485025, 485026, 485033 |
2.1.1.15 | fatty-acid O-methyltransferase |
retina |
membrane |
485161 |
2.1.1.17 | phosphatidylethanolamine N-methyltransferase |
retina |
rod outer segment |
485193 |
2.1.1.4 | acetylserotonin O-methyltransferase |
retina |
- |
441480, 441483, 441488, 719307, 734508, 756897 |
2.1.1.4 | acetylserotonin O-methyltransferase |
retina |
embryonic retina |
705249 |
2.1.1.4 | acetylserotonin O-methyltransferase |
retina |
very low levels |
441495 |
2.1.1.71 | phosphatidyl-N-methylethanolamine N-methyltransferase |
retina |
rod outer segments |
485193 |
2.3.1.108 | alpha-tubulin N-acetyltransferase |
retina |
- |
486115, 486116 |
2.3.1.108 | alpha-tubulin N-acetyltransferase |
retina |
primary cilia, inner and outer segments of retinal photoreceptor cells |
736728 |
2.3.1.135 | phosphatidylcholine-retinol O-acyltransferase |
retina |
- |
658001, 672075 |
2.3.1.135 | phosphatidylcholine-retinol O-acyltransferase |
retina |
pigmented epithelial cells |
658821, 659309 |
2.3.1.20 | diacylglycerol O-acyltransferase |
retina |
- |
737079 |
2.3.1.21 | carnitine O-palmitoyltransferase |
retina |
- |
704107 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
retina |
- |
701626 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
retina |
enzyme LPCAT1 quantitative real-time PCR expression analysis |
756687 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
retina |
mainly |
756102 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
retina |
outer rod segment |
706096 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
retina |
rod outer segment |
486650 |
2.3.1.42 | glycerone-phosphate O-acyltransferase |
retina |
in situ hybridization of DHAP-AT mRNA is performed on rat eye sections. DHAP-AT is highly expressed in the inner segment of photoreceptors and in the retinal pigment epithelium, suggesting two distinct sites for plasmalogens biosynthesis |
686595 |
2.3.1.48 | histone acetyltransferase |
retina |
- |
720032 |
2.3.1.6 | choline O-acetyltransferase |
retina |
- |
487279, 487318, 685882 |
2.3.1.6 | choline O-acetyltransferase |
retina |
ChAT protein levels are significantly increased in the dark-reared retina compared to those of the control. Light deprivation increases the expression of ChAT, increasing the apparent density of cholinergic neurons in the developing turtle retina |
687986 |
2.3.1.6 | choline O-acetyltransferase |
retina |
enzyme-containing neuronal cell bodies in only two regions, the cell islands of the optic lobe medulla and the cortical layer of the posterior olfactory lobule. Immunoreactive fibers and probable nerve terminals are found in the plexiform layer of the deep retina, within the stroma of the optic gland, and the neuropils of the optic lobe, peduncle lobe, and olfactory lobe |
687990 |
2.3.1.7 | carnitine O-acetyltransferase |
retina |
- |
487421 |
2.3.1.75 | long-chain-alcohol O-fatty-acyltransferase |
retina |
- |
757375 |
2.3.1.76 | retinol O-fatty-acyltransferase |
retina |
- |
672075 |
2.3.1.87 | aralkylamine N-acetyltransferase |
retina |
- |
-, 672840, 673102, 676921, 701705 |
2.3.1.87 | aralkylamine N-acetyltransferase |
retina |
4fold increase at night |
487633 |
2.3.1.87 | aralkylamine N-acetyltransferase |
retina |
AANAT activity is low during the daytime, increases rapidly early in the night and beginsto decline in anticipation of dawn |
676921 |
2.3.1.87 | aralkylamine N-acetyltransferase |
retina |
activity is elevated at night and rapidly inhibited by light |
676921 |
2.3.1.87 | aralkylamine N-acetyltransferase |
retina |
cultured photoreceptor cells |
487639 |
2.3.1.87 | aralkylamine N-acetyltransferase |
retina |
cultured photoreceptor cells of embryonic retina |
487639 |