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Search term: pheochromocytoma cell
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EC Number
Recommended Name
Source Tissue
Commentary
Reference
1.14.16.2
tyrosine 3-monooxygenase
pheochromocytoma cell
-
438702
,
438706
1.14.16.2
tyrosine 3-monooxygenase
pheochromocytoma cell
tumor
438690
1.14.17.1
dopamine beta-monooxygenase
pheochromocytoma cell
-
438600
1.6.1.2
NAD(P)+ transhydrogenase (Re/Si-specific)
pheochromocytoma cell
-
724435
2.1.1.28
phenylethanolamine N-methyltransferase
pheochromocytoma cell
neuroendocrine tumour of chromaffin cells
672987
2.1.1.28
phenylethanolamine N-methyltransferase
pheochromocytoma cell
pheochromocytomas are tumors of adrenal chromaffin cells. Phenylethanolamine N-methyltransferase mRNA levels are markedly increased by glucocorticoid administration. Dexamethasone elicites approximately 800fold increases in phenylethanolamine N-methyltransferase mRNA levels in mouse pheochromocytoma 862L cells and approximately 75fold increases for mouse pheochromocytoma 10/9CR1 cells. Glial cell line-derived neurotrophic factor and cpt-cAMP alone each produce little or no change in baseline phenylethanolamine N-methyltransferase mRNA levels. In both cell lines, dexamethasone-stimulated increases in phenylethanolamine N-methyltranferase mRNA levels are reduced approximately 90% by prior tratment with cAMP. Glial cell line-derived neurotrophic factor reduces dexamethasone effects on phenylethanolamine N-methyltransferase mRNA levels by 40% in mouse pheochromocytoma 862L cells, while not supressing the dexamethasone response in mouse pheochromocytoma 10/9CRC1 cells. Pretreatment with cAMP and afterwards treatment with glial cell line-derived neurotrophic factor before additon of dexamethasone reduced phenylethanolamine N-methyltransferase expression in mouse pheochromocytoma 862L and 10/9CRC1 cells to 0.1% and 5.5% of their corresponding DEX induced maxima.
673474
2.7.1.127
inositol-trisphosphate 3-kinase
pheochromocytoma cell
-
738216
2.7.1.68
1-phosphatidylinositol-4-phosphate 5-kinase
pheochromocytoma cell
-
738176
2.7.11.13
protein kinase C
pheochromocytoma cell
-
694395
2.7.11.6
[tyrosine 3-monooxygenase] kinase
pheochromocytoma cell
from adrenal gland
640693
,
640694
3.1.4.11
phosphoinositide phospholipase C
pheochromocytoma cell
expression of PLC delta
649088
3.4.22.56
caspase-3
pheochromocytoma cell
-
647613
3.5.3.18
dimethylargininase
pheochromocytoma cell
undifferentiated pheochromocytoma
699684
4.1.1.28
aromatic-L-amino-acid decarboxylase
pheochromocytoma cell
-
4225
7.6.2.1
P-type phospholipid transporter
pheochromocytoma cell
-
246839
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