EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
neutrophil |
- |
740377 |
1.1.1.43 | phosphogluconate 2-dehydrogenase |
neutrophil |
of pregnant and nonpregnant women, enzyme undergoes retrograde transport to the microtubule-organizing centers in neutrophils from pregnant women, can be blocked by colchicine, anterograde distribution in cells from nonpregnant women |
656434 |
1.1.1.47 | glucose 1-dehydrogenase [NAD(P)+] |
neutrophil |
- |
711346 |
1.1.1.49 | glucose-6-phosphate dehydrogenase (NADP+) |
neutrophil |
pregnant women, G6PD translocates to microtubule-organizing centers |
697523 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
neutrophil |
- |
671713, 671833 |
1.11.1.7 | peroxidase |
neutrophil |
- |
712228 |
1.11.2.2 | myeloperoxidase |
neutrophil |
- |
439734, 439756, 657668, 662584, 671909, 700150, 710996, 710997, 711124, 711135, 711186, 711350, 711882, 711890, 712061, 712327, 712340, 712342, 712343, 712353, 713436, 724806, 741769, 742084, 742569, 742570, 742974, 743054, 743617, 764087, 764268, 764550, 764711, 765059, 765080, 765512, 765515 |
1.11.2.2 | myeloperoxidase |
neutrophil |
neutrophilic granulocytes |
659636 |
1.13.11.27 | 4-hydroxyphenylpyruvate dioxygenase |
neutrophil |
- |
742056 |
1.13.11.31 | arachidonate 12-lipoxygenase |
neutrophil |
- |
-, 395422, 741573, 765651 |
1.13.11.33 | arachidonate 15-lipoxygenase |
neutrophil |
- |
765651 |
1.13.11.33 | arachidonate 15-lipoxygenase |
neutrophil |
low expression |
706579 |
1.13.11.33 | arachidonate 15-lipoxygenase |
neutrophil |
neutrophils do not express 15-lipoxygenase |
639267 |
1.13.11.33 | arachidonate 15-lipoxygenase |
neutrophil |
peak-II 15 lipoxygenase is the predominant enzyme form |
639240 |
1.13.11.34 | arachidonate 5-lipoxygenase |
neutrophil |
- |
439437, 439457, 660111, 673996, 675744, 689841, 704997, 705037, 705797, 711100, 742571, 765514 |
1.13.11.34 | arachidonate 5-lipoxygenase |
neutrophil |
stimulated with A23187 |
742210 |
1.13.11.34 | arachidonate 5-lipoxygenase |
neutrophil |
stimulated with the Ca2+-mobilizing agent A23187 |
742444 |
1.14.11.68 | [histone H3]-trimethyl-L-lysine27 demethylase |
neutrophil |
neutrophil JMJD3 expression is increased in patients with sepsis |
753821 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neutrophil |
of central ganglia |
743260 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neutrophil |
peritoneal polymorphonuclear |
440208, 440213 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neutrophil |
polymorphonuclear |
440208, 440213 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
neutrophil |
polymorphonuclear neutrophils, PMN |
675257 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
neutrophil |
neutrophil HO-1 expression is similar in rats receiving burn injury alone compared with shams gavaged with saline, however, as compared with rats receiving EtOH intoxication, neutrophil HO-1 expression in burn rats is significantly decreased. Furthermore, a significant decrease in neutrophil HO-1 expression is observed in rats receiving a combined insult of EtOH intoxication and burn injury compared with rats receiving either sham or burn injury alone |
688156 |
1.14.14.94 | leukotriene-B4 20-monooxygenase |
neutrophil |
- |
390069, 390073, 685340, 703413 |
1.14.14.94 | leukotriene-B4 20-monooxygenase |
neutrophil |
CYP4F2 not expressed in neutrophils |
390074 |
1.14.14.94 | leukotriene-B4 20-monooxygenase |
neutrophil |
CYP4F3A |
741555 |
1.14.14.94 | leukotriene-B4 20-monooxygenase |
neutrophil |
isoform CYP4F3A |
390071 |
1.14.16.2 | tyrosine 3-monooxygenase |
neutrophil |
- |
688723 |
1.17.3.2 | xanthine oxidase |
neutrophil |
- |
686057 |
1.17.3.2 | xanthine oxidase |
neutrophil |
from bone marrow of different samples |
684329 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
neutrophil |
- |
697280 |
1.3.1.24 | biliverdin reductase |
neutrophil |
- |
712793 |
1.6.2.2 | cytochrome-b5 reductase |
neutrophil |
- |
394210, 394216 |
1.6.2.4 | NADPH-hemoprotein reductase |
neutrophil |
peritoneal |
288547, 288548 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
neutrophil |
- |
394275, 658889, 684904, 684970, 710782, 712673, 724704, 742310 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
neutrophil |
hemorrhagic shock/resuscitation activates NAD(P)H oxidase by phosphorylation of subunit p47phox. Activation is significantly diminshed in C3H/HeJ mice, which are not responsive to lipopolysaccharide because of a point mutation of tlr4 affecting the TIR domain. In wild-type, in vitro stimulation of hemorrhagic shock/resuscitation-activated neutrophils with recombinant high-mobility group box HMGB1 causes TLR4-dependent activation of NAD(P)H oxidase as well as increased reactive oxygen species production through both MyD88-IRAK4-p38 MAPK and MyD88-IRAK4-Akt signaling pathways |
688150 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
neutrophil |
resting neutrophils |
394273 |
1.6.99.1 | NADPH dehydrogenase |
neutrophil |
- |
392802 |
1.8.5.1 | glutathione dehydrogenase (ascorbate) |
neutrophil |
- |
394019 |
2.1.1.100 | protein-S-isoprenylcysteine O-methyltransferase |
neutrophil |
light membrane fraction |
485032 |
2.2.1.2 | transaldolase |
neutrophil |
in neutrophils from nonpregnant individuals, enzyme undergoes anterograde trafficking, whereas retrograde trafficking is found during pregnacy. Trafficking involves microtubules |
675784 |
2.2.1.2 | transaldolase |
neutrophil |
the transaldolase is part of a supramolecular complex containing glucose-6-phosphate dehydrogenase in neutrophils that undergoes retrograde trafficking during pregnancy, enzyme trafficking, overview |
675784 |
2.3.1.147 | glycerophospholipid arachidonoyl-transferase (CoA-independent) |
neutrophil |
- |
16268 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
neutrophil |
- |
704442, 706096 |
2.3.1.37 | 5-aminolevulinate synthase |
neutrophil |
high expression of isoform ALAS1 |
703855 |
2.3.1.67 | 1-alkylglycerophosphocholine O-acetyltransferase |
neutrophil |
acid stress activates the enzyme |
672336 |
2.3.1.67 | 1-alkylglycerophosphocholine O-acetyltransferase |
neutrophil |
polymorphonuclear, ionophore A23187 stimulates |
487381 |
2.3.1.97 | glycylpeptide N-tetradecanoyltransferase |
neutrophil |
- |
719244 |
2.3.1.97 | glycylpeptide N-tetradecanoyltransferase |
neutrophil |
high NMT1 expression in neutrophils from the necrotic areas in inflamed lungs |
706890 |
2.3.2.2 | gamma-glutamyltransferase |
neutrophil |
- |
659102 |
2.4.1.133 | xylosylprotein 4-beta-galactosyltransferase |
neutrophil |
in the lesion site after spinal cord injury |
704802 |
2.4.1.152 | 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase |
neutrophil |
- |
736464 |
2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase |
neutrophil |
high expression level |
687078 |
2.4.2.4 | thymidine phosphorylase |
neutrophil |
- |
659750 |
2.7.1.107 | diacylglycerol kinase (ATP) |
neutrophil |
- |
640374 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
neutrophil |
- |
737400 |
2.7.1.137 | phosphatidylinositol 3-kinase |
neutrophil |
- |
640893, 640907, 640909, 688217, 709341 |
2.7.1.137 | phosphatidylinositol 3-kinase |
neutrophil |
short-term spikes of modest heat abrogate antineutrophil cytoplasmic autoantibody-induced activation of neutrophils via inhibition of PI 3-kinase/Akt signaling |
684792 |
2.7.1.137 | phosphatidylinositol 3-kinase |
neutrophil |
the regulatory subunit p87PIKAP and the catalytic subunit p101 are both expressed |
674783 |
2.7.1.138 | ceramide kinase |
neutrophil |
- |
693454, 694266 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
neutrophil |
- |
393234 |
2.7.1.23 | NAD+ kinase |
neutrophil |
- |
641201, 691390, 759217 |
2.7.1.68 | 1-phosphatidylinositol-4-phosphate 5-kinase |
neutrophil |
enzyme is enriched in the uropod during chemotaxis of primary neutrophils. Enrichment occurs early upon chemoattractant stimulation and is persistent during chemotaxis, concomitant with enrichment of phosphatidylinositol 4,5-bisphosphate |
694079 |
2.7.1.91 | sphingosine kinase |
neutrophil |
- |
661509 |
2.7.10.1 | receptor protein-tyrosine kinase |
neutrophil |
- |
660727 |
2.7.10.2 | non-specific protein-tyrosine kinase |
neutrophil |
- |
671253 |
2.7.10.2 | non-specific protein-tyrosine kinase |
neutrophil |
primary |
673956 |
2.7.11.1 | non-specific serine/threonine protein kinase |
neutrophil |
- |
742344 |
2.7.11.11 | cAMP-dependent protein kinase |
neutrophil |
from sickle cell disease patients |
672829 |
2.7.11.13 | protein kinase C |
neutrophil |
- |
702539 |
2.7.11.16 | G-protein-coupled receptor kinase |
neutrophil |
- |
671352 |
2.7.11.16 | G-protein-coupled receptor kinase |
neutrophil |
from lung |
738372 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
neutrophil |
- |
692227 |
2.7.11.18 | myosin-light-chain kinase |
neutrophil |
- |
688218 |
2.7.11.22 | cyclin-dependent kinase |
neutrophil |
- |
707917, 721986 |
2.7.11.22 | cyclin-dependent kinase |
neutrophil |
CDK 7 and CDK9 are the predominant CDKs present, with CDK5 present only at a very low level. CDK9 activity and the expression of its activating partner cyclin T1 both declined as neutrophils aged and entered apoptosis spontaneously. No cell cycle-dependent CDKs, CDK1, CDK2, CDK4 or CDK6, in neutrophils |
723580 |
2.7.11.24 | mitogen-activated protein kinase |
neutrophil |
- |
664568, 693505 |
2.7.4.21 | inositol-hexakisphosphate 5-kinase |
neutrophil |
- |
723253 |
2.7.8.2 | diacylglycerol cholinephosphotransferase |
neutrophil |
- |
644328 |
2.7.8.27 | sphingomyelin synthase |
neutrophil |
- |
723525 |
3.1.1.4 | phospholipase A2 |
neutrophil |
group IVA PLA2 isozyme |
691654 |
3.1.1.4 | phospholipase A2 |
neutrophil |
iPLA2 |
709365 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
neutrophil |
- |
681267 |
3.1.1.5 | lysophospholipase |
neutrophil |
- |
692326 |
3.1.1.77 | acyloxyacyl hydrolase |
neutrophil |
blood neutrophil |
682968 |
3.1.3.1 | alkaline phosphatase |
neutrophil |
- |
652666 |
3.1.3.36 | phosphoinositide 5-phosphatase |
neutrophil |
- |
679145, 732476 |
3.1.3.4 | phosphatidate phosphatase |
neutrophil |
- |
134887, 134897 |
3.1.3.48 | protein-tyrosine-phosphatase |
neutrophil |
receptor-type protein tyrosine phosphatase CD148 |
94993 |
3.1.3.86 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase |
neutrophil |
- |
732045 |
3.1.4.11 | phosphoinositide phospholipase C |
neutrophil |
- |
750178 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
neutrophil |
PFE9A gene expression is higher in neutrophils from sickle cell disease individuals compared to control cells |
691533 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
neutrophil |
- |
701580 |
3.1.4.4 | phospholipase D |
neutrophil |
- |
663986, 664570, 709369 |
3.1.4.4 | phospholipase D |
neutrophil |
C5 anaphylatoxin-stimulated primary neutrophils |
708460 |
3.1.4.4 | phospholipase D |
neutrophil |
expression of all four PLD1 variants: a, b, a2, and b2, as well as the a, but not the b, variant of PLD2 |
665957 |
3.1.4.4 | phospholipase D |
neutrophil |
PLD1 isthe major isoform |
664825 |
3.1.6.14 | N-acetylglucosamine-6-sulfatase |
neutrophil |
- |
663957 |
3.13.2.1 | adenosylhomocysteinase |
neutrophil |
- |
682527 |
3.2.1.166 | heparanase |
neutrophil |
- |
732436, 753404 |