EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.13.11.52 | indoleamine 2,3-dioxygenase |
natural killer cell |
- |
660498 |
1.14.11.67 | [histone H3]-trimethyl-L-lysine4 demethylase |
natural killer cell |
- |
744653 |
2.3.1.48 | histone acetyltransferase |
natural killer cell |
invariant natural killer T (iNKT) cells. Enzyme GCN5 promotes iNKT development during the maturation stage. iNKT cells undergo several well-defined developmental stages in the thymus. Dramatic accumulation of iNKT cells at the stage 0 in thymus of Gcn5 knockout mice |
-, 756394 |
2.4.1.135 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase |
natural killer cell |
- |
737068 |
2.7.1.138 | ceramide kinase |
natural killer cell |
- |
691965 |
2.7.1.91 | sphingosine kinase |
natural killer cell |
the majority of NK cells analyzed have very low sphingosine 1-phosphate phosphatase activity in comparison to sphingosine kinase activity, the majority of cells do not convert sphingosine 1-phosphate to any other detectable compound |
738428 |
2.7.10.2 | non-specific protein-tyrosine kinase |
natural killer cell |
- |
490447, 490468, 490585 |
3.1.3.67 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
natural killer cell |
- |
694494 |
3.1.4.3 | phospholipase C |
natural killer cell |
- |
652678, 679642 |
3.1.4.3 | phospholipase C |
natural killer cell |
high level of enzyme expression on the outer membrane surface. Identification of two subsets of cells, CD56dimPC-PLCbright and CD56brightPC-PLClow/-, corresponding to distinct subsets with cytolytic and immunoregulatory function. Enzyme expression level on the membrane closely correlates with that of the CD16 receptor |
679640 |
3.1.4.3 | phospholipase C |
natural killer cell |
primary natural killer cell |
651223 |
3.4.14.1 | dipeptidyl-peptidase I |
natural killer cell |
- |
664450 |
3.4.21.20 | cathepsin G |
natural killer cell |
- |
753787 |
3.4.21.39 | chymase |
natural killer cell |
- |
81385 |
3.4.21.73 | u-Plasminogen activator |
natural killer cell |
uPA localizes strongly to natural killer cells of the placental bed, especially at 8-10 weeks of gestation. uPA activity is similar in uterine natural killer cell culture supernatant compared with total unseparated decidual cells. uPA receptor in uterine natural killer cell lysates is significantly stronger than in total decidual cell lysates. Inhibitors PAI-1 and PAI-2 are not detected in uterine natural killer cell culture supernatants |
700694 |
3.4.21.78 | granzyme A |
natural killer cell |
- |
-, 731617, 755118 |
3.4.21.78 | granzyme A |
natural killer cell |
CD57+ natural killer cells |
683058 |
3.4.21.78 | granzyme A |
natural killer cell |
constitutive expression of granzyme A |
-, 752445 |
3.4.21.79 | granzyme B |
natural killer cell |
- |
-, 680720, 681010, 700200, 731617, 732723, 753168, 753362, 754488, 754761 |
3.4.21.79 | granzyme B |
natural killer cell |
a proportion of granzyme B is constitutively secreted by natural killer cells in the absence of target cell engagement. The protease is primarily released in an active form through secretory granules except in YT cells that mainly release inactive granzyme B zymogen. A-NK and NK92 cells secrete a comparatively small proportion of their granzyme B (ca. 10 and 0.3% of the total per hour, respectively), whereas YT cells release about 29% |
698217 |
3.4.21.79 | granzyme B |
natural killer cell |
express high levels of granzyme H but relatively low levels of granzyme B |
682955 |
3.4.21.79 | granzyme B |
natural killer cell |
GrB expressing cells are increased in hemophagocytic lymphohistiocytosis, enzyme expression is decreased following immunosuppressive therapy |
731864 |
3.4.21.79 | granzyme B |
natural killer cell |
highly expressed |
708696 |
3.4.21.79 | granzyme B |
natural killer cell |
is constitutively expressed |
697177 |
3.4.21.79 | granzyme B |
natural killer cell |
lysate |
29744 |
3.4.21.79 | granzyme B |
natural killer cell |
natural killer cells expressing CD16, generally express gA, gB and perforin simultaneously |
699410 |
3.4.21.79 | granzyme B |
natural killer cell |
only the YT cell line, which is a poor killer expresses low levels of GzmH |
678917 |
3.4.21.B2 | granzyme M |
natural killer cell |
- |
678965, 680787, 693462, 709988, 753186 |
3.4.21.B2 | granzyme M |
natural killer cell |
constitutively expressed |
695230 |
3.4.21.B4 | granzyme K |
natural killer cell |
- |
668480, 677803, 681971 |
3.4.21.B4 | granzyme K |
natural killer cell |
mRNA exptression |
668782 |
3.4.21.B59 | granzyme H |
natural killer cell |
- |
732517 |
3.4.22.15 | cathepsin L |
natural killer cell |
- |
712140 |
3.4.22.54 | calpain-3 |
natural killer cell |
poor expression |
649028 |
3.4.23.B24 | signal peptide peptidase |
natural killer cell |
high enzyme level |
752819 |
3.4.25.1 | proteasome endopeptidase complex |
natural killer cell |
- |
670038 |
3.6.5.5 | dynamin GTPase |
natural killer cell |
- |
699338 |
4.1.1.22 | histidine decarboxylase |
natural killer cell |
- |
693469 |