EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
myometrium |
- |
726470 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
myometrium |
HSDB1 transcript abundance in the endometrium and myometrium remain at the same level during the examined days of pregnancy. After luteolysis both endometrial and myometrial HSD3B1 expression wane |
725807 |
1.1.1.188 | prostaglandin-F synthase |
myometrium |
- |
661605 |
1.1.1.188 | prostaglandin-F synthase |
myometrium |
in pregnant myometrium, PGI2, PGD2 and PGF2 synthases are highly expressed while prostaglandin dehydrogenase is underexpressed. Myometrium from non-pregnant women has lower levels of prostaglandin synthases and higher levels of prostaglandin dehydrogenase than pregnant myometrium |
713047 |
1.1.1.188 | prostaglandin-F synthase |
myometrium |
PGH2 9-,11-endoperoxide reductase activity is expressed and active at early pregnant sows, probably also in cyclic sows |
657328 |
1.1.1.49 | glucose-6-phosphate dehydrogenase (NADP+) |
myometrium |
in patients with type 1 diabetes G6PDH activity does not differ from control group, but enzyme activity is sharply decreased in pregnant women with type 2 diabetes and gestational diabetes |
696152 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
myometrium |
moderate expression |
685803 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
myometrium |
- |
656372 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
myometrium |
three isoforms of nitric oxide synthase are mainly localized in the uterine luminal and glandular epithelium and myometrium, and the intensity of immunostaining for inducible nitric oxide synthase and endothelial nitric oxide synthase increases gradually with temporal development of the postnatal uterus. The total nitric oxide synthase and inducible nitric oxide synthase activities are significantly increased at postnatal days 21 and 35. Although constitutive nitric oxide synthase activity is increased at postnatal day 21, it decreases subsequently at postnatal day 35. Inducible nitric oxide synthase protein expression is significantly increased at postnatal days 21 and 35 |
723884 |
1.14.99.1 | prostaglandin-endoperoxide synthase |
myometrium |
- |
438395 |
1.3.99.6 | 3-oxo-5beta-steroid 4-dehydrogenase |
myometrium |
relative expression decreases significantly in association with labour by about 10fold |
676039 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
myometrium |
NADPH oxidase mediates angiotensin II-stimulated protein synthesis downstream of the type 1 receptor AT1 in myometrium smooth muscle cells |
696573 |
2.1.1.28 | phenylethanolamine N-methyltransferase |
myometrium |
low activity |
639444 |
2.1.1.6 | catechol O-methyltransferase |
myometrium |
levels of staining for the COMT protein in myometrium are highest on day 1 and lowest on days 8 and 13, but high levels returned by days 16 and 19 of pregnancy. Modulation of COMT activity may play a role in the regulation of myometrial contractility and cervical ripening during pregnancy |
690007 |
2.1.1.6 | catechol O-methyltransferase |
myometrium |
modulation of COMT activity may play a role in the regulation of myometrial contractility and cervical ripening during pregnancy |
690007 |
2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase |
myometrium |
moderate expression of PI3K-C2alpha |
645046 |
2.7.1.91 | sphingosine kinase |
myometrium |
- |
671224 |
2.7.1.91 | sphingosine kinase |
myometrium |
during gestation, isoforms Sphk1 and Sphk2 are co-expressed. The levels and activity of SphK1/2 are modest at midgestation , increase at day 19 and progressively decline to low at postpartum. Inhibition of protein kinase C and ERK reduces SphK1/2 activity. In primary cultures of myometrial cells from day 19 pregnant rats, induction of COX2 is mediated by 4-phorbol 12,13-dibutyrate and IL-1 through sequential activation of protein kinase C, ERK1/2, and SphK1. Sphingosine 1-phosphate produced by SphK1 is released in the medium. In day 12 myometrial tissues, the release of sphingosine 1-phosphate is markedly reduced in association with low levels of SphK1 and COX2 |
703466 |
2.7.11.16 | G-protein-coupled receptor kinase |
myometrium |
primary cells |
661600 |
2.7.11.18 | myosin-light-chain kinase |
myometrium |
- |
640627, 640632 |
2.7.11.18 | myosin-light-chain kinase |
myometrium |
pregnant sheep myometrium, turkey and chicken gizzard enzyme are immunologically related |
640626 |
2.7.8.29 | L-serine-phosphatidylethanolamine phosphatidyltransferase |
myometrium |
high level of expression |
717766 |
2.8.1.2 | 3-mercaptopyruvate sulfurtransferase |
myometrium |
- |
645559 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
myometrium |
at least 2 isozymes I and II |
650505 |
3.1.3.9 | glucose-6-phosphatase |
myometrium |
- |
134945 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
myometrium |
myometrial cell, level of isoform PDE1C decreases in all conditions that inhibit proliferation |
667433 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
myometrium |
- |
667433 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
myometrium |
myometrial cell, level of isoform PDE5 decreases in all conditions that inhibit proliferation |
667433 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
myometrium |
pregnant and non-pregnant |
670025 |
3.4.14.2 | dipeptidyl-peptidase II |
myometrium |
smooth muscle cells |
650796 |
3.4.14.4 | dipeptidyl-peptidase III |
myometrium |
- |
683562 |
3.4.23.5 | cathepsin D |
myometrium |
- |
36917 |
3.4.24.24 | gelatinase A |
myometrium |
derived from premenopausal women aged 45-55 years who underwent total abdominal hysterectomy |
683507 |
3.4.24.61 | nardilysin |
myometrium |
- |
695465 |
3.5.3.1 | arginase |
myometrium |
significant decrease of enzyme activity during 7th-21st day of gestation, significant increase in enzyme activity at term gestation, day 22. Gestational changes in enzyme activity negatively correlate with those in cyclic GMP production and positively correlate with those in endogenous NO synthase inhibitors and endothelin-1 contents. Enhanced enzyme activity at term gestation may be implicated in increasing myometrial contractions mediated by increase in endothelin-1 |
670290 |
4.4.1.1 | cystathionine gamma-lyase |
myometrium |
pregnant myometrium, primarily localized to smooth muscle cells of pregnant myometrium |
716719 |
5.3.3.1 | steroid DELTA-isomerase |
myometrium |
- |
725807 |
5.3.99.3 | prostaglandin-E synthase |
myometrium |
- |
661310, 747232 |
5.3.99.3 | prostaglandin-E synthase |
myometrium |
expressed to a lesser extent |
661310 |
5.3.99.3 | prostaglandin-E synthase |
myometrium |
intermediate abundance of the protein |
661605 |
5.3.99.3 | prostaglandin-E synthase |
myometrium |
isoform mPGES-1 localizes mostly in myometrial and vascular smooth muscle cells of pregnant women. Isoform cPGES is diffusely located throughout the myometrium. Expression of COX-2 and isoform mPGES-1 mRNA with term labour, whereas cPGES expression does not change. Interleukin 1beta stimulates release of prostaglandin E2 by myometrical smooth muscle cells and increases COX-2 and mPGES-1 mRNA and protein expression |
681963 |
5.3.99.3 | prostaglandin-E synthase |
myometrium |
isoform mPGES-2 protein is largely in stromal cells surrounding smooth vascular muscle. Expression of mPGES-2 mRNA increases with term labour and preterm labour |
681963 |
5.3.99.3 | prostaglandin-E synthase |
myometrium |
myometrial smooth muscle cell |
679515 |
5.6.1.8 | myosin ATPase |
myometrium |
- |
751639 |
7.2.2.10 | P-type Ca2+ transporter |
myometrium |
- |
210480 |