EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
monocyte |
- |
700302 |
1.1.1.49 | glucose-6-phosphate dehydrogenase (NADP+) |
monocyte |
- |
655495 |
1.11.2.2 | myeloperoxidase |
monocyte |
- |
439767 |
1.13.11.31 | arachidonate 12-lipoxygenase |
monocyte |
- |
726846 |
1.13.11.33 | arachidonate 15-lipoxygenase |
monocyte |
- |
-, 675201, 742845 |
1.13.11.34 | arachidonate 5-lipoxygenase |
monocyte |
- |
704997, 711100, 742001, 743614 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
monocyte |
- |
395473 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
monocyte |
induced by alpha-, beta- and gamma-interferon |
666895 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
monocyte |
monocytes are a major source of active IDO in normal peripheral blood |
712647 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
monocyte |
constitutive expression of full length nitric oxide synthase isoforms. Isolated monocytes express more endothelial nitric oxide synthase transcript and protein as compared to neuronal nitric oxide synthase and inducible nitric oxide synthase |
724425 |
1.14.13.9 | kynurenine 3-monooxygenase |
monocyte |
- |
348533, 763915 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
monocyte |
- |
684932, 688160, 733904 |
1.14.14.94 | leukotriene-B4 20-monooxygenase |
monocyte |
- |
685340 |
1.14.15.18 | calcidiol 1-monooxygenase |
monocyte |
- |
674992, 675057 |
1.14.16.5 | alkylglycerol monooxygenase |
monocyte |
- |
746303 |
1.14.99.1 | prostaglandin-endoperoxide synthase |
monocyte |
isozyme 2 |
438405 |
1.14.99.38 | cholesterol 25-monooxygenase |
monocyte |
- |
744738 |
1.16.3.1 | ferroxidase |
monocyte |
- |
438021 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
monocyte |
- |
697280 |
1.3.1.21 | 7-dehydrocholesterol reductase |
monocyte |
- |
349277 |
1.3.1.24 | biliverdin reductase |
monocyte |
- |
740486 |
1.3.98.3 | coproporphyrinogen dehydrogenase |
monocyte |
- |
711084 |
1.5.1.34 | 6,7-dihydropteridine reductase |
monocyte |
- |
656444 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
monocyte |
- |
688216 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
monocyte |
subunit gp91phox gene expression is significantly higher in monocytes from sickle cell disease patients compared with normal controls. Monocytes from patients show higher levels of p47phox phosphorylation compared with normal controls |
684278 |
1.7.1.7 | GMP reductase |
monocyte |
peripheral |
659550 |
1.8.5.1 | glutathione dehydrogenase (ascorbate) |
monocyte |
- |
394019 |
2.1.1.356 | [histone H3]-lysine27 N-trimethyltransferase |
monocyte |
- |
705683 |
2.1.1.364 | [histone H3]-lysine4 N-methyltransferase |
monocyte |
- |
704436 |
2.2.1.1 | transketolase |
monocyte |
at the lesion border |
694176 |
2.3.1.147 | glycerophospholipid arachidonoyl-transferase (CoA-independent) |
monocyte |
- |
16266, 16269, 718983 |
2.3.1.147 | glycerophospholipid arachidonoyl-transferase (CoA-independent) |
monocyte |
HL-60 monocytic leukemia cells |
16267 |
2.3.1.147 | glycerophospholipid arachidonoyl-transferase (CoA-independent) |
monocyte |
U937 cell line |
16274 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
monocyte |
- |
658221, 658887, 704950, 706096, 736546 |
2.3.1.26 | sterol O-acyltransferase |
monocyte |
- |
486696, 660878, 703975 |
2.3.1.26 | sterol O-acyltransferase |
monocyte |
serotonin upregiulates ACAT-1 expression in human monocyte-macrophages |
671677 |
2.3.1.48 | histone acetyltransferase |
monocyte |
leukemic |
487090 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
monocyte |
- |
736141 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
monocyte |
- |
722417 |
2.4.1.255 | protein O-GlcNAc transferase |
monocyte |
- |
721485 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
monocyte |
- |
735872 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
monocyte |
isolated from total PBMCs from blood from healthy individuals |
694813 |
2.4.3.1 | beta-galactoside alpha-(2,6)-sialyltransferase |
monocyte |
- |
722730 |
2.4.3.9 | lactosylceramide alpha-2,3-sialyltransferase |
monocyte |
- |
705676, 721691 |
2.7.1.1 | hexokinase |
monocyte |
- |
737993 |
2.7.1.137 | phosphatidylinositol 3-kinase |
monocyte |
- |
640862, 640887, 710681 |
2.7.1.137 | phosphatidylinositol 3-kinase |
monocyte |
U937 monocyte |
640862 |
2.7.1.36 | mevalonate kinase |
monocyte |
- |
693507 |
2.7.1.91 | sphingosine kinase |
monocyte |
- |
675032 |
2.7.1.91 | sphingosine kinase |
monocyte |
secretion of sphinganine 1-phosphate |
661860 |
2.7.10.1 | receptor protein-tyrosine kinase |
monocyte |
- |
490220, 490593, 673570 |
2.7.10.2 | non-specific protein-tyrosine kinase |
monocyte |
- |
662575, 671253, 673959, 674876, 691455 |
2.7.10.2 | non-specific protein-tyrosine kinase |
monocyte |
bone marrow-derived |
490355 |
2.7.10.2 | non-specific protein-tyrosine kinase |
monocyte |
bone marrow-derived monocytic cells |
490249 |
2.7.10.2 | non-specific protein-tyrosine kinase |
monocyte |
monocyte tumor cell lines |
490248 |
2.7.10.2 | non-specific protein-tyrosine kinase |
monocyte |
primary |
672781 |
2.7.11.1 | non-specific serine/threonine protein kinase |
monocyte |
- |
738091, 742344 |
2.7.11.10 | IkappaB kinase |
monocyte |
- |
662570 |
2.7.11.24 | mitogen-activated protein kinase |
monocyte |
- |
691301, 705321 |
2.7.11.24 | mitogen-activated protein kinase |
monocyte |
low activity |
491714 |
2.7.11.26 | tau-protein kinase |
monocyte |
- |
704992 |
2.7.12.1 | dual-specificity kinase |
monocyte |
bone marrow monocyte |
761591 |
2.7.4.9 | dTMP kinase |
monocyte |
upregulation in monocyte/macrophage differentiating cells |
692491 |
2.8.1.1 | thiosulfate sulfurtransferase |
monocyte |
- |
724781 |
2.8.2.29 | [heparan sulfate]-glucosamine 3-sulfotransferase 2 |
monocyte |
- |
760623 |
2.8.2.30 | [heparan sulfate]-glucosamine 3-sulfotransferase 3 |
monocyte |
- |
738746 |
2.8.2.30 | [heparan sulfate]-glucosamine 3-sulfotransferase 3 |
monocyte |
the enzyme is not detected in primary monocytes |
760623 |
2.8.2.8 | [heparan sulfate]-glucosamine N-sulfotransferase |
monocyte |
high expression level of isozyme NDST2. The expression of NDST2 in monocytes is modified following cell activation or maturation, although the same treatment has no significant effect on the level of mRNAencoding NDST1 |
704666 |
3.1.1.1 | carboxylesterase |
monocyte |
- |
691075 |
3.1.1.1 | carboxylesterase |
monocyte |
at least 4 major isoenzymes |
170979 |
3.1.1.1 | carboxylesterase |
monocyte |
CES1, no expression of CES2 |
707570 |
3.1.1.13 | sterol esterase |
monocyte |
- |
714756 |
3.1.1.2 | arylesterase |
monocyte |
- |
749762 |
3.1.1.25 | 1,4-lactonase |
monocyte |
- |
749762 |
3.1.1.31 | 6-phosphogluconolactonase |
monocyte |
- |
80873 |
3.1.1.34 | lipoprotein lipase |
monocyte |
- |
664174, 708067 |
3.1.1.4 | phospholipase A2 |
monocyte |
- |
681856 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
monocyte |
enzyme activity increases during differentiation, only monocyte-derived dendritic cells show highly reduced enzyme expression |
652685 |
3.1.3.11 | fructose-bisphosphatase |
monocyte |
peripheral blood monocyte |
664494 |
3.1.3.11 | fructose-bisphosphatase |
monocyte |
peripheral blood monocyte. baseline activity of fructose 1,6-bisphosphatase in cancer patients is 1.0 nmol/min/mg protein, and 4.4 nmol/min/mg for healthy volunteers |
664494 |
3.1.3.48 | protein-tyrosine-phosphatase |
monocyte |
- |
653879 |
3.1.4.1 | phosphodiesterase I |
monocyte |
- |
730060 |
3.1.4.12 | sphingomyelin phosphodiesterase |
monocyte |
- |
730060 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
monocyte |
- |
712187 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
monocyte |
monocytic cells may express different PDE4 isozymes, depending on their state of activation or differentiation. These isozymes could thus regulate intracellular cAMP levels at various stages of monocyte activation and could thereby be important in limiting the inflammatory response |
689066 |
3.2.1.18 | exo-alpha-sialidase |
monocyte |
- |
654541 |
3.2.1.18 | exo-alpha-sialidase |
monocyte |
low expression of Neu-2 and Neu-3 |
654541 |
3.2.1.45 | glucosylceramidase |
monocyte |
- |
136451, 136453 |
3.2.1.45 | glucosylceramidase |
monocyte |
Gaucher disease |
136467 |
3.3.2.6 | leukotriene-A4 hydrolase |
monocyte |
- |
708038, 708048, 708181 |
3.3.2.9 | microsomal epoxide hydrolase |
monocyte |
- |
663275 |
3.4.11.2 | membrane alanyl aminopeptidase |
monocyte |
- |
663607, 665112, 699295, 701354 |
3.4.11.2 | membrane alanyl aminopeptidase |
monocyte |
alveolar monocyte |
699938 |
3.4.11.2 | membrane alanyl aminopeptidase |
monocyte |
functional co-localization of monocytic and THP1 cell enzyme with the Fc gamma receptors CD32 and CD64 |
663873 |
3.4.11.2 | membrane alanyl aminopeptidase |
monocyte |
of percardial fluid |
665244 |
3.4.11.2 | membrane alanyl aminopeptidase |
monocyte |
of peripheral blood |
665955, 665958 |
3.4.14.5 | dipeptidyl-peptidase IV |
monocyte |
- |
699938 |
3.4.15.1 | peptidyl-dipeptidase A |
monocyte |
- |
81241 |
3.4.15.1 | peptidyl-dipeptidase A |
monocyte |
classical, CD14++CD16- cells |
753311 |
3.4.15.1 | peptidyl-dipeptidase A |
monocyte |
mice with expression of angiotensin convertzing enzyme only in monocytes and macrophages have a marked resistance to the growth of melanoma due to an enhanced immune response |
680175 |