EC Number   |
Recommended Name |
Source Tissue |
Reference |
|---|
   3.4.21.79 | granzyme B |
cytotoxic T-lymphocyte cell line |
- |
681748, 682947, 682955 |
| 3.4.21.79 | granzyme B |
cytotoxic T-lymphocyte cell line |
a proportion of granzyme B is constitutively secreted by cytotoxic T lymphocytes in the absence of target cell engagement. Cytotoxic T lymphocyte primarily secrete inactive granzyme B zymogen, bypassing the granules. They produce less granzyme B than natural killer cells, but secrete much more (58%) than they store |
698217 |
| 3.4.21.79 | granzyme B |
cytotoxic T-lymphocyte cell line |
expresses gzmB. Positive gzmB cytotoxic T-lymphocyte cells abrogate target cell proliferation by inducing cell death, independent of caspases and mitochondrial signaling. Positive gzmB cytotoxic T-lymphocyte cells independently induce pro-apoptotic processes either via caspase-3/-7, leading to plasma membrane perturbance and ROS production or via Bid/Bak/Bax, resulting in cytochrome c release, whereby both pathways elicit loss of mitochondrial membrane potential |
679102 |
| 3.4.21.79 | granzyme B |
cytotoxic T-lymphocyte cell line |
of activated CTL lines, grown in the presence of recombinant interleukin 2 |
29743 |
