EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
MCF-7 cell |
high enzyme expression level |
668162 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
MCF-7 cell |
- |
700182 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
MCF-7 cell |
- |
743697, 760802 |
1.1.1.188 | prostaglandin-F synthase |
MCF-7 cell |
- |
697271, 740999 |
1.1.1.22 | UDP-glucose 6-dehydrogenase |
MCF-7 cell |
- |
697937 |
1.1.1.239 | 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) |
MCF-7 cell |
- |
712882 |
1.1.1.27 | L-lactate dehydrogenase |
MCF-7 cell |
- |
740254 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
MCF-7 cell |
- |
763396 |
1.1.1.34 | hydroxymethylglutaryl-CoA reductase (NADPH) |
MCF-7 cell |
- |
668139 |
1.1.1.357 | 3alpha-hydroxysteroid 3-dehydrogenase |
MCF-7 cell |
- |
740017 |
1.1.1.37 | malate dehydrogenase |
MCF-7 cell |
- |
760678 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
MCF-7 cell |
- |
761332 |
1.1.1.44 | phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) |
MCF-7 cell |
- |
760664 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
MCF-7 cell |
- |
740017 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
MCF-7 cell |
- |
285981, 287195, 287199, 287200, 700184, 762481 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
MCF-7 cell |
breast cancer cell line MCF-7 |
285981, 287200 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
MCF-7 cell |
MCF-7.8H cell derived from MCF-7 via transfection, high enzyme activity |
670262 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
MCF-7 cell |
modulation of local synthesis of estradiol is one potential mechanism through which genistein, enterolactone and enterodiol may protect against breast cancer |
670035 |
1.1.1.64 | testosterone 17beta-dehydrogenase (NADP+) |
MCF-7 cell |
- |
740912 |
1.1.1.8 | glycerol-3-phosphate dehydrogenase (NAD+) |
MCF-7 cell |
- |
762072 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
MCF-7 cell |
- |
711694 |
1.1.99.39 | D-2-hydroxyglutarate dehydrogenase |
MCF-7 cell |
- |
763736 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
MCF-7 cell |
treatment with docosahexaenoic acid results in 90% decrease in GPx-4 level |
688924 |
1.11.1.24 | thioredoxin-dependent peroxiredoxin |
MCF-7 cell |
- |
687918 |
1.11.1.8 | iodide peroxidase |
MCF-7 cell |
- |
765648 |
1.13.11.33 | arachidonate 15-lipoxygenase |
MCF-7 cell |
- |
673030 |
1.13.11.53 | acireductone dioxygenase (Ni2+-requiring) |
MCF-7 cell |
- |
764226 |
1.14.11.29 | hypoxia-inducible factor-proline dioxygenase |
MCF-7 cell |
- |
743581 |
1.14.11.30 | hypoxia-inducible factor-asparagine dioxygenase |
MCF-7 cell |
- |
742895 |
1.14.11.53 | mRNA N6-methyladenine demethylase |
MCF-7 cell |
- |
739559 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
MCF-7 cell |
- |
701223, 744782 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
MCF-7 cell |
- |
711677, 726380, 764400 |
1.14.11.67 | [histone H3]-trimethyl-L-lysine4 demethylase |
MCF-7 cell |
- |
757659, 758215, 765418, 765640 |
1.14.11.67 | [histone H3]-trimethyl-L-lysine4 demethylase |
MCF-7 cell |
high KDM5B expression level |
744657 |
1.14.11.67 | [histone H3]-trimethyl-L-lysine4 demethylase |
MCF-7 cell |
PLU-1-mediated H3K4 demethylase activity plays an important role in the proliferative capacity of breast cancer cells through repression of tumor suppressor genes, including BRCA1 |
688944 |
1.14.14.1 | unspecific monooxygenase |
MCF-7 cell |
CYP1A1, CYP1A2 and CYP1B1 |
706841 |
1.14.14.14 | aromatase |
MCF-7 cell |
- |
764633, 765383, 765426 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
MCF-7 cell |
- |
688928, 734531 |
1.14.15.18 | calcidiol 1-monooxygenase |
MCF-7 cell |
- |
671357, 672857 |
1.14.15.18 | calcidiol 1-monooxygenase |
MCF-7 cell |
expression of 1alpha-OHase is 1.25fold higher in MCF-7 compared to MCF-10A cells. MCF-7 cells show no or marginal expression levels of splice variants |
685920 |
1.14.19.17 | sphingolipid 4-desaturase |
MCF-7 cell |
- |
744398, 744686, 745595 |
1.14.19.44 | acyl-CoA (8-3)-desaturase |
MCF-7 cell |
- |
734434 |
1.14.99.1 | prostaglandin-endoperoxide synthase |
MCF-7 cell |
- |
744616 |
1.15.1.1 | superoxide dismutase |
MCF-7 cell |
- |
716197 |
1.17.1.4 | xanthine dehydrogenase |
MCF-7 cell |
- |
687917 |
1.17.1.4 | xanthine dehydrogenase |
MCF-7 cell |
low XDH expression and activity |
704789 |
1.17.3.2 | xanthine oxidase |
MCF-7 cell |
tumor cell line |
686529 |
1.17.4.1 | ribonucleoside-diphosphate reductase |
MCF-7 cell |
a breast carcinoma cell line |
688283 |
1.2.1.12 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) |
MCF-7 cell |
- |
743173 |
1.2.1.13 | glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) |
MCF-7 cell |
- |
672334 |
1.21.99.4 | thyroxine 5'-deiodinase |
MCF-7 cell |
- |
744792 |
1.3.1.24 | biliverdin reductase |
MCF-7 cell |
- |
740411 |
1.4.3.13 | protein-lysine 6-oxidase |
MCF-7 cell |
- |
687920, 713156 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
MCF-7 cell |
- |
711685, 762877 |
1.5.3.17 | non-specific polyamine oxidase |
MCF-7 cell |
- |
764224 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
MCF-7 cell |
- |
673704, 694497, 713005, 713018, 724516 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
MCF-7 cell |
oxidative stress-resistant MCF-7 breast cancer cells, derived from MCF-7 cells, which were rendered resistant by chronic exposure to an H2O2-generating system made by mixing a redox cycler (menadione) with a reducing agent such as ascorbate. |
745663 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
MCF-7 cell |
wild-type p53 breast cancer cell lines MCF7 transfected with MCF7-NQO1 to overexpress NQO1, MCF7-SUP8 to knockdown NQO1 |
689130 |
1.6.5.5 | NADPH:quinone reductase |
MCF-7 cell |
- |
715414 |
1.8.1.7 | glutathione-disulfide reductase |
MCF-7 cell |
- |
712066 |
1.8.1.9 | thioredoxin-disulfide reductase |
MCF-7 cell |
- |
675915, 685557, 689751, 697613, 711283 |
1.8.98.2 | sulfiredoxin |
MCF-7 cell |
- |
700520 |
2.1.1.1 | nicotinamide N-methyltransferase |
MCF-7 cell |
no expression of NNMT in |
687897 |
2.1.1.100 | protein-S-isoprenylcysteine O-methyltransferase |
MCF-7 cell |
- |
757874 |
2.1.1.244 | protein N-terminal methyltransferase |
MCF-7 cell |
- |
736919, 756463 |
2.1.1.319 | type I protein arginine methyltransferase |
MCF-7 cell |
- |
756861 |
2.1.1.320 | type II protein arginine methyltransferase |
MCF-7 cell |
- |
757401, 757657 |
2.1.1.321 | type III protein arginine methyltransferase |
MCF-7 cell |
- |
755900, 757636 |
2.1.1.355 | [histone H3]-lysine9 N-trimethyltransferase |
MCF-7 cell |
- |
755156 |
2.1.1.359 | [histone H3]-lysine36 N-trimethyltransferase |
MCF-7 cell |
- |
703137 |
2.1.1.361 | [histone H4]-lysine20 N-methyltransferase |
MCF-7 cell |
- |
753133, 754107 |
2.1.1.45 | thymidylate synthase |
MCF-7 cell |
- |
703391, 756169 |
2.1.1.56 | mRNA (guanine-N7)-methyltransferase |
MCF-7 cell |
- |
757896 |
2.1.1.6 | catechol O-methyltransferase |
MCF-7 cell |
- |
685970, 702405, 703319, 703321 |
2.1.1.77 | protein-L-isoaspartate(D-aspartate) O-methyltransferase |
MCF-7 cell |
- |
733251 |
2.1.2.1 | glycine hydroxymethyltransferase |
MCF-7 cell |
- |
674506, 704565, 704566 |
2.1.2.2 | phosphoribosylglycinamide formyltransferase 1 |
MCF-7 cell |
- |
756648 |
2.1.2.3 | phosphoribosylaminoimidazolecarboxamide formyltransferase |
MCF-7 cell |
- |
756648 |
2.1.2.3 | phosphoribosylaminoimidazolecarboxamide formyltransferase |
MCF-7 cell |
breast cancer cell |
172161, 172163 |
2.1.3.2 | aspartate carbamoyltransferase |
MCF-7 cell |
- |
756715 |
2.3.1.147 | glycerophospholipid arachidonoyl-transferase (CoA-independent) |
MCF-7 cell |
estrogen receptor-positive breast cancer cell |
658381 |
2.3.1.225 | protein S-acyltransferase |
MCF-7 cell |
- |
756336 |
2.3.1.24 | sphingosine N-acyltransferase |
MCF-7 cell |
- |
736471, 754096 |
2.3.1.24 | sphingosine N-acyltransferase |
MCF-7 cell |
CerS2 and CerS6 are the major very long-chain and long-chain CerS isoforms in MCF-7 cells, respectively |
754096 |
2.3.1.255 | N-terminal amino-acid Nalpha-acetyltransferase NatA |
MCF-7 cell |
- |
702870 |
2.3.1.256 | N-terminal methionine Nalpha-acetyltransferase NatC |
MCF-7 cell |
- |
756860 |
2.3.1.297 | very-long-chain ceramide synthase |
MCF-7 cell |
CerS2 and CerS6 are the major very long-chain and long-chain CerS isoforms in MCF-7 cells, respectively |
754096 |
2.3.1.299 | sphingoid base N-stearoyltransferase |
MCF-7 cell |
- |
754096 |
2.3.1.48 | histone acetyltransferase |
MCF-7 cell |
- |
686096, 703846, 735352, 756658, 758109 |
2.3.1.5 | arylamine N-acetyltransferase |
MCF-7 cell |
- |
659440, 686948, 689073 |
2.3.1.5 | arylamine N-acetyltransferase |
MCF-7 cell |
breast cancer cell line, estrogen receptor (ER)-positive, expression below detection limits in Western blot analysis |
686948 |
2.3.1.5 | arylamine N-acetyltransferase |
MCF-7 cell |
mammary carcinoma cell line, NAT1 |
675802 |
2.3.1.85 | fatty-acid synthase system |
MCF-7 cell |
- |
704079, 705999, 720118, 736065, 736603 |
2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (NAD+) |
MCF-7 cell |
- |
756689, 757667 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
MCF-7 cell |
- |
719171 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
MCF-7 cell |
breast cancer cell line |
659317 |
2.3.2.32 | cullin-RING-type E3 NEDD8 transferase |
MCF-7 cell |
- |
745773 |
2.3.3.8 | ATP citrate synthase |
MCF-7 cell |
- |
756335 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
MCF-7 cell |
- |
759404 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
MCF-7 cell |
- |
703956 |