EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
Leydig cell |
- |
668423, 698503, 699111, 740997 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
Leydig cell |
- |
655347, 670252, 699841, 726493, 741248 |
1.1.1.188 | prostaglandin-F synthase |
Leydig cell |
co-localization of cyclooxygenase-1, prostaglandin F receptor and prostaglandin F synthase |
687013 |
1.1.1.239 | 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) |
Leydig cell |
pre- and peri-pubertal changes promote expression of the enzyme in Leydig cells |
713574 |
1.1.1.300 | NADP-retinol dehydrogenase |
Leydig cell |
- |
761195 |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
Leydig cell |
- |
686929, 761195 |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
Leydig cell |
3beta- and 17beta-hydroxysteroid dehydrogenase are not altered in metyrapone-treated cells |
690081 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
Leydig cell |
3beta- and 17beta-hydroxysteroid dehydrogenase are not altered in metyrapone-treated cells |
690081 |
1.1.1.64 | testosterone 17beta-dehydrogenase (NADP+) |
Leydig cell |
- |
699111, 726493 |
1.1.1.64 | testosterone 17beta-dehydrogenase (NADP+) |
Leydig cell |
17beta-HSD type 3 (HSD17B3) is expressed almost exclusively in testicular Leydig cells |
761760 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
Leydig cell |
of neonatal pig. High expression of 11beta-hydroxysteroid dehydrogenase type 2 mRNA, resulting in oxidation from cortisol to cortison, with no detection of the reduction reaction. Activity of type 2 enzyme is higher than the oxidation activity of the type 1 enzyme |
693882 |
1.13.11.71 | carotenoid-9',10'-cleaving dioxygenase |
Leydig cell |
- |
720152 |
1.14.14.154 | sterol 14alpha-demethylase |
Leydig cell |
- |
671727 |
1.14.14.17 | squalene monooxygenase |
Leydig cell |
tumor cell defective in cytochrome P450 17alpha hydroxylase/17,20 lyase activity |
659953 |
1.14.14.19 | steroid 17alpha-monooxygenase |
Leydig cell |
- |
715984 |
1.14.14.24 | vitamin D 25-hydroxylase |
Leydig cell |
- |
736019 |
1.14.14.32 | 17alpha-hydroxyprogesterone deacetylase |
Leydig cell |
- |
706819 |
1.14.14.32 | 17alpha-hydroxyprogesterone deacetylase |
Leydig cell |
intensely present during the breeding season and weakly present during the non-breeding season |
705389 |
1.14.15.4 | steroid 11beta-monooxygenase |
Leydig cell |
- |
655347 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
Leydig cell |
- |
712924, 743937 |
1.2.3.1 | aldehyde oxidase |
Leydig cell |
ABCA1 and AOX1 are coexpressed |
692569 |
1.3.1.21 | 7-dehydrocholesterol reductase |
Leydig cell |
progenitor cells, immature cells, and adult cells, differentially expressed transcripts and enzyme expression levels during development and differentiation, overview |
656789 |
1.4.3.1 | D-aspartate oxidase |
Leydig cell |
- |
711719 |
1.7.2.1 | nitrite reductase (NO-forming) |
Leydig cell |
MLTC-1 |
677146 |
1.8.1.9 | thioredoxin-disulfide reductase |
Leydig cell |
TXNRD1_v3 is predominantly expressed in the Leydig cells |
687762 |
2.3.1.176 | propanoyl-CoA C-acyltransferase |
Leydig cell |
- |
758130 |
2.3.1.37 | 5-aminolevulinate synthase |
Leydig cell |
high expression of isoform ALAS1 |
703855 |
2.7.1.154 | phosphatidylinositol-4-phosphate 3-kinase |
Leydig cell |
strong expression of PI3K-C2alpha and moderate expression of PI3K-C2beta |
645046 |
2.7.11.22 | cyclin-dependent kinase |
Leydig cell |
- |
707637 |
2.7.12.2 | mitogen-activated protein kinase kinase |
Leydig cell |
- |
678560 |
2.8.2.2 | alcohol sulfotransferase |
Leydig cell |
- |
761704 |
3.1.1.13 | sterol esterase |
Leydig cell |
temperature-stabile enzyme enriched |
133846 |
3.1.1.79 | hormone-sensitive lipase |
Leydig cell |
- |
-, 730033 |
3.1.2.2 | palmitoyl-CoA hydrolase |
Leydig cell |
- |
666097 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
Leydig cell |
phosphodiesterase 5 |
668864 |
3.1.6.2 | steryl-sulfatase |
Leydig cell |
all cells with positive StS expression,exception: 65.1% StS expression in 50-day-old animal's Leydig cells |
695080 |
3.2.1.114 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase |
Leydig cell |
in the Golgi apparatus |
646640 |
3.4.11.6 | aminopeptidase B |
Leydig cell |
- |
665109, 666799 |
3.4.16.5 | carboxypeptidase C |
Leydig cell |
of testis |
665905 |
3.4.17.23 | angiotensin-converting enzyme 2 |
Leydig cell |
- |
763160 |
3.4.17.23 | angiotensin-converting enzyme 2 |
Leydig cell |
ACE2 may participate in the control of the testicular function |
668418 |
3.4.21.34 | plasma kallikrein |
Leydig cell |
synthesis of prekallikrein |
683208 |
3.4.21.35 | tissue kallikrein |
Leydig cell |
- |
665230, 671024 |
3.4.21.B42 | hippostasin |
Leydig cell |
expression revealed by immunohistochemistry |
667873 |
3.4.22.62 | caspase-9 |
Leydig cell |
- |
697784 |
3.4.23.5 | cathepsin D |
Leydig cell |
- |
731091 |
3.6.4.13 | RNA helicase |
Leydig cell |
- |
691843 |
3.6.4.13 | RNA helicase |
Leydig cell |
the 1 kb fragment (5' to the ATG codon) of GRTH gene contains sequences for androgen regulation of its expression in Leydig cells |
712550 |
4.1.1.15 | glutamate decarboxylase |
Leydig cell |
- |
701446 |
4.1.1.29 | sulfinoalanine decarboxylase |
Leydig cell |
- |
701655 |
4.1.1.49 | phosphoenolpyruvate carboxykinase (ATP) |
Leydig cell |
- |
727933 |
4.3.2.9 | gamma-glutamylcyclotransferase |
Leydig cell |
weak expression |
720332 |
4.4.1.16 | selenocysteine lyase |
Leydig cell |
- |
730241 |
4.6.1.2 | guanylate cyclase |
Leydig cell |
- |
679514, 679516 |
6.2.1.3 | long-chain-fatty-acid-CoA ligase |
Leydig cell |
- |
653671, 661822, 671606, 675688 |