EC Number   |
General Information |
Reference |
|---|
   7.4.2.1 | evolution |
the enzyme belongs to the GAP gene family |
719380 |
| 7.4.2.1 | evolution |
the enzyme belongs to the large amino acid/auxin permease family |
718559 |
| 7.4.2.1 | malfunction |
shoot and root nitrogen supply are strongly decreased in enzyme-silenced plants, while nitrogen fixation and nodule metabolism are up-regulated in these plants |
748336 |
| 7.4.2.1 | malfunction |
suppression of two enzyme genes (AAAP15 and AAAP21) significantly increases the mortality of adult whiteflies |
747962 |
| 7.4.2.1 | malfunction |
trafficking of Gap1p mutants with altered substrate specificity and transport activity, overview |
720414 |
| 7.4.2.1 | metabolism |
LysR-type ArgP and global regulator Lrp are transcriptional regulators of gene lysP, which is also regulated by the concentration of exogenous available lysine. Lysine-loaded ArgP and arginine-loaded ArgP compete at the lysP promoter. ArgP binds to the lysP promoter/control region at a T-N11-A motif in the presence and absence of lysine. Lysine-loaded ArgP prevents lysP transcription at the promoter clearance step and is a major regulator of lysP expression, Lrp modulates lysP transcription under lysine-limiting conditions by direct binding to its control region |
719724 |
| 7.4.2.1 | metabolism |
the enzyme catalyzes the transmembrane transport of single amino acid, multiple amino acids, auxin (indole-3-acetic acid) or gamma-aminobutyric acid |
747962 |
| 7.4.2.1 | metabolism |
the enzyme is a key player in nitrogen retrieval from the apoplasm into inner cortex cells for nodule export |
748336 |
| 7.4.2.1 | physiological function |
Candida albicans Gap2, CaGap2, is the true orthologue of Saccharomyces cerevisiae Gap1, which not only mediates the uptake of most amino acids but also functions as a receptor for the activation of protein kinase A, as it transports all tested amino acids. The other CaGap proteins have narrower substrate specificities though CaGap1 and CaGap6 transport several structurally unrelated amino acids. CaGap1, CaGap2, and CaGap6 also function as sensors, e.g. for methionine. CaGap permeases communicate to the intracellular signal transduction pathway |
719380 |
| 7.4.2.1 | physiological function |
the enzyme generates inward glutamine-dependent currents and regulates glutamine import into bacteriocytes |
747169 |
