EC Number   |
General Information |
Reference |
|---|
   6.3.4.20 | evolution |
the enzyme belongs to GAT-QueC, a two-domain family with an N-terminal glutamine amidotransferase class-II domain fused to a domain homologous to QueC, the enzyme that produces preQ0. Phylogenetic distribution of aTGT, ArcS, GAT-QueC, and QueF-like in the two archaeal phyla, overview. Most crenarchaeal genomes encode a fused GAT-QueC protein or a QueF-like protein |
717018 |
| 6.3.4.20 | malfunction |
the expression of QueC from a plasmid-borne copy confers a Q+ phenotype to enzyme-deficient mutant strain Escherichia coli B105 |
717724 |
| 6.3.4.20 | metabolism |
the enzyme is involved in biosynthetic pathways towards deazapurine-containing compounds |
-, 744701 |
| 6.3.4.20 | metabolism |
the metabolic pathway includes the conversion of the biosynthetic intermediate, 6-carboxy-5,6,7,8-tetrahydropterin, to intermediate, 7-carboxy-7-deazaguanine, CDG, by an unusual transformation catalyzed by QueE, a member of the radical SAM enzyme superfamily. The carboxylate moiety on CDG is converted subsequently to a nitrile to yield preQ0 by QueC in an ATP-dependent reaction, in which ammonia serves as the nitrogen source. CDG may be the central precursor to all deazapurines, biosynthesis of deazapurine containing compounds in nature incorporates H2NTP, CPH4 and CDG as common intermediates |
717240 |
| 6.3.4.20 | metabolism |
the products of four genes, queC, queD, queE, and queF, are involved in preQ1 biosynthesis with GTP as the starting material. preQ1 is transformed to Q in tRNA |
718371 |
| 6.3.4.20 | metabolism |
the queC (ybaX) gene product functions in the initial step of queuosine biosynthetic pathway in Escherichia coli, queuosine incorporation in tRNAs, overview |
717724 |
| 6.3.4.20 | physiological function |
involvement of QueC at a step leading to production of preQ0, intermediate in the pathway that utilizes GTP as the starting molecule to produce queuosine, overview |
717724 |
| 6.3.4.20 | physiological function |
the enzyme QueC produces the G+ precursor, 7-cyano-7-deazaguanine, i.e. preQ0, which is inserted into tRNA by tRNA-guanine transglycosylase before conversion into G+ by archaeosine synthase, ArcS. Gat-QueC and QueF-like families can compensate for lack of ArcS, overview |
717018 |
