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Results 1 - 7 of 7
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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.19malfunction partial inactivation of tilS in vivo results in an AUA codon-dependent translational defect 705717
Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.19malfunction the absence of enzyme activity leads to a lack of modification of cytidine34 to lysidine in tRNA2IleLAU, (i.e. synthesis of tRNA2IleCAU), thereby rendering it inactive for translation of AUA codons. Strains of Bacillus subtilis carrying a deletion in the TilS gene can survive only in the presence of a mutant tRNA1Ile, whose anticodon wobble position is changed from G34 to U34 (tRNA1IleUAU) -, 728408
Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.19physiological function 2-lysyl cytidine is a lysine-containing cytidine derivative commonly found at the wobble position of bacterial AUA codon-specific tRNAIle. This modification determines both codon and amino acid specificities of tRNAIle 705718
Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.19physiological function bacteria decode the isoleucine codon AUA using a tRNA species that is posttranscriptionally modified at the wobble position of the anticodon with a lysine-containing cytidine derivative called lysidine. The lysidine modification of tRNAIle2 is an essential identity determinant for proper aminoacylation by isoleucyl tRNA synthetase and codon recognition on the ribosome. The ATP- and lysine-dependent formation of lysidine is catalyzed by tRNAIle-lysidine synthetase 704642
Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.19physiological function enzyme catalyzes the lysylation of C34 in the precursor tRNAIle(CAU), thereby leading to the formation of tRNAIle(lysidineAU). The formation of lysidine by this essential enzyme allows recognition of tRNAIle(lysidineCAU) by Ile-tRNA synthetase and switches the base pairing of the tRNA from AUG (Met) to AUA (Ile). TilS is essential and plays a crucial role in accurate decoding and hence viability of cells 706867
Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.19physiological function the enzyme generates lysidine at the wobble position of tRNAIle. The enzyme is essential for the decoding of AUA codons in the cell 705717
Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.19physiological function the single 2-lysylcytidine modification converts the codon-specificity from AUG to AUA, and the amino acid specificity from Met to Ile 703735
Results 1 - 7 of 7
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