EC Number   |
General Information |
Reference |
|---|
    6.3.4.13 | malfunction |
gart and paics mutants have pigmentation defects and microphthalmia |
703376 |
| 6.3.4.13 | metabolism |
Pur2,5 encodes a bifunctional enzyme that catalyzes the second and the fifth steps of de novo purine biosynthesis pathway andshows dual enzymatic activity - of glycinamide ribotide synthetase and of aminoim-idazole ribotide synthetase |
728250 |
| 6.3.4.13 | metabolism |
the trifunctional enzyme catalyzes steps 2, 3, and 5 of inosine monophosphate synthesis, followed by paics encoded phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase, a bifunctional enzyme that catalyzes steps 6 and 7 of this process. Crucial requirement for maternally derived gart and paics. De novo purine synthesis pathway, overview |
703376 |
| 6.3.4.13 | physiological function |
gart and paics function are required for eye growth. IMP feeds into an ATP pathway required for retinoblast proliferation and a GTP pathway required for pigmentation |
703376 |
