EC Number   |
General Information |
Reference |
|---|
    5.4.2.8 | evolution |
the enzyme belongs to the alpha-D-phosphohexomutase superfamily of enzymes |
-, 728329 |
| 5.4.2.8 | metabolism |
alpha-phosphomannomutase1 is required for GDP-mannose and dolichol-phosphate-mannose biosynthesis |
715973 |
| 5.4.2.8 | more |
analysis of conformational flexibility of different forms of phosphoglucomutase/phosphomannomutase in solution, including its active, phosphorylated state and the unphosphorylated state that occurs transiently during the catalytic cycle, by hydrogen-deuterium exchange by mass spectrometry and small angle x-ray scattering. Both ligand binding and phosphorylation of the catalytic phosphoserine affect the overall flexibility of the enzyme in solution |
727988 |
| 5.4.2.8 | more |
the cap domain contributes the residues involved in substrate recognition, E119, R121, M124, N126, R132, R139, S177, so that the active site is located in the groove at the interface of the core and cap domains |
-, 728329 |
| 5.4.2.8 | physiological function |
phosphomannomutase is important in the direct or/and indirect control of antibiotic production |
701872 |
| 5.4.2.8 | physiological function |
the enzyme catalyzes an intramolecular phosphoryl transfer across its phosphosugar substrates, which are precursors in the synthesis of exoproducts involved in bacterial virulence |
727988 |
| 5.4.2.8 | physiological function |
the enzyme is essential for parasite growth. It takes over the function of phosphoglucomutase, EC 5.4.2.2, whose gene is lost in Trypanosoma brucei, together with phosphoacetylglucosamine mutase, EC 5.4.2.3, producing D-glucose 1-phosphate from D-glucose 6-phosphate, kinetics, overview |
-, 728329 |
| 5.4.2.8 | physiological function |
the enzyme is involved in biosynthesis of sphingans, extracellular polysaccharides |
-, 727228 |
