EC Number   |
General Information |
Reference |
|---|
    5.4.2.2 | evolution |
the enzyme belongs to the alpha-D-phosphohexomutase enzyme superfamily |
727479 |
| 5.4.2.2 | malfunction |
an enzyme-deficient mutant shows significantly reduced survival in embryonic trophoblast cells and in mice, and induces high protective immunity in BALB/c mice. Moreover, the mutant elicits an anti-Brucella-specific immunoglobulin G response and induces the secretion of gamma interferon and interleukin-2 |
-, 749424 |
| 5.4.2.2 | malfunction |
complete enzyme loss results in dwarf growth, prematurely die off, and inability to develop a functional inflorescence |
749141 |
| 5.4.2.2 | malfunction |
enzyme depletion is associated with declined cellular glycogen content and decreased rates of glycogenolysis and glycogenesis. Furthermore, enzyme depletion suppresses cell proliferation under long-term repetitive glucose depletion |
747766 |
| 5.4.2.2 | malfunction |
enzyme loss causes male sterility |
748330 |
| 5.4.2.2 | malfunction |
only mutants with a deletion of PGM3, not of PGM1 or PGM2, hyperaccumulate ribose-1-phosphate |
727521 |
| 5.4.2.2 | malfunction |
targeted deletion of pgmA in Yersinia pestis strain KIM5 results in loss of autoaggregation, the deletion mutant displays more than 1000fold increased sensitivity to polymyxin B compared to the parental strain |
-, 704004 |
| 5.4.2.2 | malfunction |
the pgm deletion mutant has impaired growth in vitro, is deficient in the ability to utilize alpha-D-galactose as a carbon source and displays reduced O-antigen polymer length |
-, 705571 |
| 5.4.2.2 | malfunction |
whereas pgm2 and pgm3 single mutants are undistinguishable from the wild type, loss of both PGM2 and PGM3 severely impairs male and female gametophyte function. Double mutant pollen completes development but fails to germinate, double mutant ovules also develop normally, but approximately half remain unfertilized 2 d after pollination |
-, 716605 |
| 5.4.2.2 | metabolism |
cytosolic PGM activity is not limiting for carbon metabolism |
-, 716605 |
