EC Number   |
General Information |
Reference |
|---|
  5.1.3.38 | metabolism |
the enzyme participates in erythritol catabolism. Erythritol is an important nutrient for Brucella, a worldwide pathogen that finds this four-carbon polyol in genital tissues |
-, 737165 |
| 5.1.3.38 | physiological function |
allelic exchange mutants in eryC of Brucella suis are erythritol sensitive in vitro with a minimal inhibitory concentration of 1 to 5 mM of erythritol. Their multiplication in macrophage-like cells is 50- to 90fold reduced, but complementation of the mutant restores wild-type levels of intracellular multiplication and the capacity to use erythritol as a sole carbon source. In vivo, the eryC mutant colonize the spleens of infected BALB/c mice to a significantly lower extent than the wild-type. eryC mutants that are in addition spontaneously erythritol tolerant nevertheless exhibit wild-type-like intramacrophagic and intramurine replication |
-, 738366 |
| 5.1.3.38 | physiological function |
the ery operon expression is higher in Brucella melitensis infected embryonic trophoblast cells (HPT8 cells) compared with the medium. The relative expression of eryA, eryB and eryC peaks at 2 h post?infection in HPT8 cells, and eryD expression peaks at 3 h post infection. The expression of eryA, eryB and eryC may be inhibited by increased eryD expression. The expression of the ery operon is stable in the presence of erythritol in cells |
738187 |
