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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.15evolution the deduced amino acid sequence of ACLR from Ensifer sp. 23-3 exhibits high similarity (99%) to that of aspartate aminotransferase family protein (UniProt ID W8HW01) from Ensifer adhaerens strain OV14 748352
Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.15evolution the enzyme belongs to the fold-type I PLP-dependent enzyme family 746781
Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.15malfunction the mutation of either Asp210 or Lys267 to alanine abolish the racemization activity for 2-aminohexano-6-lactam 746781
Display the word mapDisplay the reaction diagram Show all sequences 5.1.1.15more analysis of the structure-function relationship, overview. Lys241 is a key amino acid residue, active site structure of ACL racemase. The substrate binding site is typically located between Trp49 and Tyr137. Lys241 Nepsilon is considered to be important for recognizing the carbonyl O of the substrate. Lys241 also forms a salt bridge with Glu396. Asp210 and Lys267 are two plausible acid/base catalytic candidate residues, situated on the re and si faces of the pyridoxal 5'-phosphate ring, respectively. The racemization of ACL racemase proceeds via a two-base mechanism 746781
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