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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 4.4.1.3physiological function comparison of DMSP lyases and lyase-like enzymes. Two conserved sequence motifs of the superfamily include the metal-ligating residues that are absolutely essential and other residues including an active site tyrosine that seems to play a relatively minor role in DMSP lysis 747144
Display the word mapDisplay the reaction diagram Show all sequences 4.4.1.3physiological function DMSP decomposition employs a concerted beta-elimination mechanism, where the substrate alpha-proton abstraction by residue Asp377 is coupled with the Cbeta-S bond dissociation and Calpha-Cbeta double bond formation. The reaction proceeds without any Omy species bridging the two ferric ions, although an Omy bridging species is observed in the crystal structures. A neutral residue Lys419 may be more favorable for the catalysis than protonated Lys419 -, 748278
Results 1 - 2 of 2