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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 4.2.2.8more intermolecular disulfide bond formation in HepI important for catalysis, overview 714553
Display the word mapDisplay the reaction diagram Show all sequences 4.2.2.8physiological function differential effects of heparitinase I and heparitinase III, EC 4.2.2.7, on endothelial tube formation. The enzymes inhibit tube formation and reduce tumor-derived neovascularization in vivo by reducing bFGF binding and subsequent signaling, HepIII has a stronger effect than Hep I. Heparitinases, isolated from Flavobacterium heparinum, cleave heparan sulfate chains at defined locations, Hep I cleaves heparin sulfate chains containing glucuronic acid residues adjacent to glucosamine residues containing either N-acetyl or N-sulfate groups. Hep I generates fragments that retain their growth factor binding capability and therefore still potentiate tube formation 714027
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