EC Number   |
General Information |
Reference |
|---|
    4.2.1.47 | evolution |
GMD belongs to the reductase-epimerase-dehydrogenase superfamily which has a catalytic triad, Ser-Tyr-Lys, that is highly conserved |
-, 715079 |
| 4.2.1.47 | malfunction |
mutations in this enzyme participate in the progression of colorectal cancer |
730740 |
| 4.2.1.47 | metabolism |
GMD catalyzes the first step in the de novo synthesis pathways of GDP-L-fucose, overview |
702081 |
| 4.2.1.47 | metabolism |
the enzyme is required for Fng-dependent Notch signaling and the fucosylation of bulk proteins |
730812 |
| 4.2.1.47 | metabolism |
the enzyme is required for the first step of fucose synthesis. The enzyme is a cytosolic partner of tankyrase 1 that inhibits its poly(ADP-ribose) polymerase activity and influences its stability |
730379 |
| 4.2.1.47 | metabolism |
the first step of the de novo pathway starting from GDP-D-mannose is a dehydration reaction catalysed by the specific nucleotide-sugar dehydratase GMD resulting in GDP-L-fucose synthesis |
716479 |
| 4.2.1.47 | physiological function |
GMD is involved in the breakdown of ingested polysaccharides into a form that could not be absorbed and utilized by the host otherwise |
-, 715079 |
