EC Number |
General Information |
Reference |
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3.7.1.8 | evolution |
BphD belongs to meta-cleavage product (MCP) hydrolases which possesses an alpha/beta-hydrolase fold and utilizes a Ser-His-Asp triad during catalysis |
735243 |
3.7.1.8 | evolution |
meta-cleavage product (MCP) hydrolases are members of the alpha/beta-hydrolase superfamily that utilize a Ser-His-Asp triad to catalyze the hydrolysis of a C?C bond |
719664 |
3.7.1.8 | evolution |
the enzyme belongs to the alpha/beta-hydrolase superfamily |
-, 733047 |
3.7.1.8 | malfunction |
rapid acylation of the H265Q variant during C-C bond cleavage suggests that the serinate forms via a substrate-assisted mechanism in the reaction |
718941 |
3.7.1.8 | metabolism |
BphD is a meta-cleavage product (MCP) hydrolase which catalyzes C-C bond fission in the aerobic catabolism of aromatic compounds by bacteria utilizing a Ser-His-Asp triad to catalyze hydrolysis via an acyl-enzyme intermediate |
718941 |
3.7.1.8 | metabolism |
BphD is the MCP hydrolase from the biphenyl degradation pathway and hydrolyzes 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to 2-hydroxypenta-2,4-dienoic acid (HPD) and benzoate |
719664 |
3.7.1.8 | metabolism |
enzyme is involved in metabolism of 2,2'-dihydroxybiphenyl |
-, 722479 |
3.7.1.8 | metabolism |
meta-cleavage product hydrolase BphD is the fourth enzyme of the biphenyl catabolic pathway |
735243 |
3.7.1.8 | metabolism |
the enzyme is involved in the biodegradation of biphenyl |
755881 |
3.7.1.8 | more |
energy profiles of three individual pathways along substrate-assisted acylation (Ser112-His265-Asp237 involved) and deacylation pathways |
735243 |