    3.7.1.3 | metabolism |
the role of the enzyme (KYNU) in cancer cell proliferation, tumour growth and development is evaluated by MTT assay, soft agar colony formation assay and xenograft mouse models. Among 137 primary breast cancer tissues, 46.7% (64/137) have high KYNU expression while 53.3% have low KYNU expression. The expression of KYNU is positively correlated with the expressions of biomarkers ER, PR and E-cad, while negatively associated with tumour grade, tumour stage and the expressions of biomarker HER2 and Ki-67. Overexpression of KYNU significantly inhibits cell proliferation in cell culture, colony formation in soft agar and xenograft BC development in NOD/SCID mice. Kynureninase suppresses breast cancer cell proliferation, tumour growth and development |
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