EC Number |
General Information |
Reference |
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3.5.4.5 | evolution |
an active-site Thr/Ser is conserved in mammalian DNA cytidine deaminases, overview |
719945 |
3.5.4.5 | evolution |
APOBEC3G belongs to an APOBEC superfamily containing at least 11 members |
721103 |
3.5.4.5 | malfunction |
CD domain switch or replacement greatly affect the sensitivity to Vif induced degradation, editing and antiviral activity of hA3G, but the replacement or switch of CDs has no effect on hA3G viral incorporation, overview. The mutants show a nucleotide sequence preference pattern |
721103 |
3.5.4.5 | malfunction |
cytidine deaminase-deficient APOBEC3G lacks antiviral activity when expressed within physiological levels in T cells |
713581 |
3.5.4.5 | malfunction |
impaired central B-cell tolerance and increased serum autoAb in Aicda-/- mice compared to the wild-type |
720915 |
3.5.4.5 | malfunction |
loss-of-function mutations of AID fail to undergo SHM |
711168 |
3.5.4.5 | malfunction |
patients with hyper-IgM syndromes who are deficient in activation-induced cytidine deaminase, which is required for class switch recombination and somatic hypermutation, are prone to develop autoimmune diseases. Defective peripheral B-cell tolerance checkpoint occurs in AID-deficient patients, overview |
720914 |
3.5.4.5 | malfunction |
phospho-mimetic variants fail to mediate isotype switching in activated mouse splenic B lymphocytes or suppress HIV-1 replication in human T cells. Phospho-null alanine mutants maintain intrinsic DNA deaminase activity, whereas phosphomimetic glutamate mutants are inactive |
719945 |
3.5.4.5 | metabolism |
CDA is a pyrimidine salvage pathway enzyme that recycles cytidine and 20-deoxycytidine for uridine and 2-deoxyuridine synthesis, respectively |
-, 712889 |
3.5.4.5 | metabolism |
cytidine deaminase is a key enzyme in the pyrimidine salvage pathway |
-, 718695 |