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Results 1 - 10 of 24 > >>
EC Number General Information Commentary Reference
Show all pathways known for 3.5.4.5Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.5evolution an active-site Thr/Ser is conserved in mammalian DNA cytidine deaminases, overview 719945
Show all pathways known for 3.5.4.5Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.5evolution APOBEC3G belongs to an APOBEC superfamily containing at least 11 members 721103
Show all pathways known for 3.5.4.5Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.5malfunction CD domain switch or replacement greatly affect the sensitivity to Vif induced degradation, editing and antiviral activity of hA3G, but the replacement or switch of CDs has no effect on hA3G viral incorporation, overview. The mutants show a nucleotide sequence preference pattern 721103
Show all pathways known for 3.5.4.5Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.5malfunction cytidine deaminase-deficient APOBEC3G lacks antiviral activity when expressed within physiological levels in T cells 713581
Show all pathways known for 3.5.4.5Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.5malfunction impaired central B-cell tolerance and increased serum autoAb in Aicda-/- mice compared to the wild-type 720915
Show all pathways known for 3.5.4.5Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.5malfunction loss-of-function mutations of AID fail to undergo SHM 711168
Show all pathways known for 3.5.4.5Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.5malfunction patients with hyper-IgM syndromes who are deficient in activation-induced cytidine deaminase, which is required for class switch recombination and somatic hypermutation, are prone to develop autoimmune diseases. Defective peripheral B-cell tolerance checkpoint occurs in AID-deficient patients, overview 720914
Show all pathways known for 3.5.4.5Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.5malfunction phospho-mimetic variants fail to mediate isotype switching in activated mouse splenic B lymphocytes or suppress HIV-1 replication in human T cells. Phospho-null alanine mutants maintain intrinsic DNA deaminase activity, whereas phosphomimetic glutamate mutants are inactive 719945
Show all pathways known for 3.5.4.5Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.5metabolism CDA is a pyrimidine salvage pathway enzyme that recycles cytidine and 20-deoxycytidine for uridine and 2’-deoxyuridine synthesis, respectively -, 712889
Show all pathways known for 3.5.4.5Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.5metabolism cytidine deaminase is a key enzyme in the pyrimidine salvage pathway -, 718695
Results 1 - 10 of 24 > >>