EC Number   |
General Information |
Reference |
|---|
    3.5.1.42 | evolution |
the enzyme belongs to the NMN deamidase family |
-, 755141 |
| 3.5.1.42 | evolution |
the enzyme belongs to the PncC superfamily, active site configuration, structure comparisons, overview |
733870 |
| 3.5.1.42 | evolution |
the enzyme's N-terminal domain belongs to the COG1058 family and is associated with the ADP-ribose pyrophosphatase activity |
-, 734285 |
| 3.5.1.42 | metabolism |
nicotinamide mononucleotide (NMN) deamidase is one of the key enzymes of the bacterial pyridine nucleotide cycle, PNC |
-, 735110 |
| 3.5.1.42 | metabolism |
the enzyme is associated with natural competence and is proposed to have a function as an enzyme participating in the pyridine nucleotide cycle, which recycles products formed by non-redox uses of NAD+ |
-, 734285 |
| 3.5.1.42 | metabolism |
the hyperthermophilic archaeon Thermococcus kodakarensis utilizes a four-step pathway for NAD+ salvage through nicotinamide deamination |
-, 754020 |
| 3.5.1.42 | metabolism |
the only possible way of nicotinamide salvage in Shewanella oneidensis |
719984 |
| 3.5.1.42 | more |
enzyme surface charge analysis and substrate docking performed on the enzyme structure from Agrobacterium tumefaciens, PDB code 2A9S, overview |
733870 |
| 3.5.1.42 | more |
mutational analysis of AtCinA supports the Ser/Lys catalytic dyad mechanism, overview |
-, 755141 |
| 3.5.1.42 | physiological function |
recombinant NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo. NMN-consuming activity with axonal NAD-synthesizing enzyme NMNAT2, but not NAD-synthesizing activity, and it delays axon degeneration in primary neuronal cultures. Transgenic NMN deamidase protection is neuron specific and effective against various toxic insults. NMN deamidase prevents NMN accumulation in injured sciatic nerves |
753342 |
