EC Number   |
General Information |
Reference |
|---|
   3.4.24.B2 | evolution |
enzyme PepF is a metallopeptidase belonging to the M3 family |
-, 753677 |
| 3.4.24.B2 | evolution |
the enzyme belongs to the M3B subfamily of metallopeptidases and displays the highest amino acid sequence identity (40.3%) to the oligopeptidase PepFBa from mesophilic Bacillus amyloliquefaciens 23-7A among the characterized oligopeptidases |
-, 734466 |
| 3.4.24.B2 | malfunction |
the mutant strain TM90, in which gene pepF, encoding oligopeptidase F, is disturbed, shows significant upregulation of biofilm formation compared to the parental strain. The TM90 colony phenotype is smaller, more transparent, and splendent. The adhesive ability of TM90 to HEP-G2 cells is significantly increased compared with the parental strain. Fifty percent lethal dose (LD50) determinations in zebrafish demonstrats that the enhanced-biofilm mutant TM90 is highly attenuated relative to the wild-type strain |
-, 753677 |
| 3.4.24.B2 | physiological function |
Aeromonas hydrophila oligopeptidase F, encoded by gene pepF, is negatively involved in biofilm formation. Enzyme PepF might contribute to Aeromonas hydrophila virulence |
-, 753677 |
