EC Number   |
General Information |
Reference |
|---|
   3.4.24.34 | malfunction |
abrogation of MMP-8 activity by specific inhibitors as well as transfection with MMP-8 siRNA abolishes production of the cleavage fragment and occludin remained attached to the cell periphery |
718303 |
| 3.4.24.34 | malfunction |
intracerebroventricular microinjection of MMP8-specific shRNA lentivirus reduces the extent of ischemia-induced brain damage, as assessed by infarct volume, neurological score, microglial activation, and TNF-alpha expression. Administration of an MMP8 inhibitor (M8I) immediately after reperfusion reduced brain damage |
754776 |
| 3.4.24.34 | malfunction |
ischemia-reperfusion (I/R) injury leads to increased expression of intestinal and systemic MMP8. Inhibition of MMP8 prevents intestinal barrier dysfunction following I/R injury. MMP8-null mice have reduced intestinal permeability to FD-40 compared with wild-type mice. Wild-type mice treated with MMP8 inhibitor also have a significant reduction of intestinal neutrophil infiltration as compared with wild-type mice treated with vehicle. Claudin-3 expression is reduced after I/R injury, relative to the respective sham-treated animals, and this effect is ameliorated by either genetic ablation or pharmacologic inhibition of MMP8. Inhibition of MMP8 decreases neutrophil infiltration in the intestine and lung and prevents intestinal damage, myeloperoxidase activity is reduced, overview |
-, 753531 |
| 3.4.24.34 | malfunction |
juvenile MMP8 null mice have greater mortality and higher bacterial burden than wild-type mice. Leukocyte counts and cytokine concentrations in the peritoneal fluid are increased in the MMP8 null mice relative to the wild-type mice. Peritoneal macrophages from MMP8 null mice have reduced phagocytic capacity compared to wild-type macrophages. There is no quantitative difference in NET formation, but fewer bacteria are adherent to NETs from MMP8 null animals |
-, 754754 |
| 3.4.24.34 | malfunction |
MMP-8-/- mice with acute lung injury have greater increases in lung polymorphonuclear neutrophils (PMNs) and macrophage counts, measures of alveolar capillary barrier injury, lung elastance, and mortality than wild-type mice with acute lung injury |
717929 |
| 3.4.24.34 | more |
MMP-8 differs from other MMPs in that it has an insertion that enlarges its active site |
755297 |
| 3.4.24.34 | more |
MMP-8 is critical for dexamethasone therapy in alkali-burned corneas under dry eye conditions. The anti-inflammatory effects of Dex are mediated through increased MMP-8 expression |
-, 754245 |
| 3.4.24.34 | physiological function |
aortic rings isolated from MMP8 -/- apoE -/- mice have less endothelial cell sprouting, and endothelial cells in MMP8 -/- apoE -/- mice have a lower ability to migrate into Matrigel plugs and less capacity of proliferation and angiogenesis. MMP8 -/- apoE -/- and MMP8 +/+- apoE -/- mice fed a Western diet for 12 have small lesion size and less endothelial cells within atherosclerotic lesions |
733615 |
| 3.4.24.34 | physiological function |
knockdown of MMP-8 in human umbilical vein endothelial cells with MMP-8 shRNA lentivirus results in a decrease in in vitro capillary-like network formation, cell proliferation and migration, and impairs its capacity of in vivo angiogenesis. Less nuclear accumulation of beta-catenin and lower beta-catenin target gene expression levels are observed in the HuVECs expressing lower levels of endogenous MMP-8. MMP8 is expressed in microvessels within human atherosclerotic plaques and aneurysm. Knockdown of endogenous MMP-8 down-regulates platelet/endothelial cell adhesion molecule PECAM-1 expression by converting less angiotensin I to II, which is an inducer for PECAM-1 gene expression |
733615 |
| 3.4.24.34 | physiological function |
matrix metalloproteinase-8 augments bacterial clearance in a juvenile sepsis model. Developmental age influences the role of MMP8 in sepsis, mechanism by which MMP8 influences outcomes in sepsis, analysis of local cytokine response in juvenile wild-type and MMP8 null mice with peritoneal sepsis, overview |
-, 754754 |
