EC Number   |
General Information |
Reference |
|---|
   3.4.22.68 | evolution |
in humans, the SENP/ULP protease family is comprised of seven members, six are SUMO-specific proteases, SENP1, SENP2, SENP3, SENP5, SENP6, and SENP7, whereas one is specific for another ubiquitin-like protein, Nedd8, or SENP8, also named DEN1 or NEDP1. SENP6 and SENP7 are the most divergent members in their conserved catalytic domain |
717852 |
| 3.4.22.68 | evolution |
Plasmodium falciparum has only two predicted SENP proteases whereas human hosts have six SENPs |
717481 |
| 3.4.22.68 | evolution |
SENP1 is a member of SENP family |
714646 |
| 3.4.22.68 | malfunction |
an ulp1 temperature-sensitive strain ulp1-333SGG with inactivated enzyme Ulp1 at restrictive temperature accumulates unprocessed SUMO protein |
-, 732389 |
| 3.4.22.68 | malfunction |
cells lacking SENP6 show defects in spindle assembly and metaphase chromosome congression. A subset of proteins become undetectable on inner kinetochores after SENP6 depletion, particularly the CENP-H/I/K complex, whereas other changes in kinetochore composition mimick defects previously reported to result from CENP-H/I/K depletion, SENP6 depletion results in loss of the CENP-H/I/K complex from kinetochores, detailed overview |
715706 |
| 3.4.22.68 | malfunction |
growth defects caused by loss of ESD4 function are not due to increased synthesis of the stress signal salicylic acid, enzyme depletion causes delay in flowering |
718246 |
| 3.4.22.68 | malfunction |
growth defects caused by loss of ESD4 function are not due to increased synthesis of the stress signal salicylic acid. ELS1 depletion causes no measurable alterations in flowering and leaf development |
718246 |
| 3.4.22.68 | malfunction |
slencing of SENP1 inhibits growth and colony formation of DLD-1 cells, results in G1-phase arrest, and upregulates the expression of some CDK inhibitors, overview |
714646 |
| 3.4.22.68 | malfunction |
targeted disruption of SENP2 impairs the G-S transition required for mitotic and endoreupliation cell cycles during expansion of trophoblast stem cells and their differentiation into polyploidy cells, respectively. The disruption disturbs the subcellular distribution and SUMO modification of Mdm2, leading to interference with p53 degradation. SUMO conjugated Mdm2 is elevated in the SENP2-null cells |
714673 |
| 3.4.22.68 | more |
active site residue is Cys461 |
718246 |
