EC Number   |
General Information |
Reference |
|---|
   3.4.22.60 | malfunction |
caspase-7-deficient MEF cells are not resistance to intrinsic cell death, but remain attached to the extracellular matrix |
731550 |
| 3.4.22.60 | malfunction |
caspase-7-deficient mice still possesses apoptotic cells in the primary enamel knot in a similar distribution to the wild type |
731227 |
| 3.4.22.60 | malfunction |
deletion of caspase-7 inhibits TNF-induced cleavage and activation of A-SMase |
717539 |
| 3.4.22.60 | malfunction |
depletion of caspase-7 from the cytoplasmic extracts of valproate-induced BCBL-1 cells reduces the cleavage of ORF57, and inhibition of caspase-7 activity promotes the expression of ORF59 |
717785 |
| 3.4.22.60 | malfunction |
enzyme-deficient mice show a significant decrease in mineral density of endochondral bones |
731608 |
| 3.4.22.60 | malfunction |
mice lacking caspase-7 and its macrophages allow substantial Legionella pneumophila replication. This permissiveness of caspase-7-deficient macrophages to the intracellular pathogen is due to defective delivery of the organism to the lysosome and to delayed cell death during early stages of infection |
732797 |
| 3.4.22.60 | malfunction |
there is a significant decrease in the amount of mineralized tissue in caspase-7 knockout mice |
731701 |
| 3.4.22.60 | more |
active caspase-7 colocalizes with internalized TNF-R1 receptosomes. TNF-induced caspase-7 activation takes place exclusively within TNF receptosomes |
717539 |
| 3.4.22.60 | physiological function |
caspase-7 activation is sufficient to start apoptosis, but it requires mitochondrial contribution to fully commit |
731042 |
| 3.4.22.60 | physiological function |
caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 in the cytoplasm confers a cellular function against viral lytic gene expression. But only initiator caspase-8, EC 3.4.22.61, is triggered in BCBL-1 cells with lytic KSHV induction by valproate, along with cleavage of expressed ORF57. Caspase-7 is an essential caspase in the cleavage of KSHV ORF57 and plays a key role in ORF57 cleavage in BCBL-1 cells during KSHV lytic infection |
717785 |
