EC Number |
General Information |
Reference |
---|
3.4.22.40 | malfunction |
bleomycin hydrolase knockout mice excrete up to 10fold more L-homocysteine-thiolactone than normal animals |
717080 |
3.4.22.40 | malfunction |
knockdown of bleomycin hydrolase reduces cp-2 cleavage, and ameliorates mutant huntingtin induced toxicity |
717821 |
3.4.22.40 | malfunction |
proteins involved in lipid homeostasis (ApoE), energy metabolism (Atp5h), oxidative stress response (Sod1), nitric oxide generation (Ddah1), and metabolic detoxification (Glo1, Sult1c1) were differentially expressed in livers of bleomycin hydrolase-null mice. Proteins involved in lipoprotein metabolism (ApoA1), antigen processing (Psme1), energy metabolism (Gamt), catechol metabolism (Comt) show differential expression in bleomycin hydrolase-deficient mice only in animals fed with a hyperhomocysteinemic diet |
731117 |
3.4.22.40 | malfunction |
the sensitivity to bleomycin is increased in HeLa cells after knockdown of bleomycin hydrolase |
731954 |
3.4.22.40 | metabolism |
Ubc9 plays different roles of action in antitumor agents in chemotherapy. The process requires bleomycin hydrolase and poly(ADP-ribose) polymerase-1 |
753931 |
3.4.22.40 | physiological function |
bleomycin hydrolase protects against L-homocysteine-thiolactone toxicity in brain and kidney |
717080 |