EC Number |
General Information |
Reference |
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3.2.2.31 | malfunction |
an enzyme-knockout strain displays a 36fold higher frequency of spontaneous mutations than the wild type strain. Enzyme gene disruption causes increased sensitivity to H2O2 but not UV irradiation |
745780 |
3.2.2.31 | physiological function |
the enzyme can remove misincorporated adenine opposite guanine or 7,8-dihydro-8-oxoguanine on the template strand during DNA replication. The enzyme has a role in preventing the mutagenic effects of 5-hydroxyuracil |
744263 |
3.2.2.31 | physiological function |
the enzyme in the prevention of mutations and the repair of oxidative DNA lesions |
745065 |
3.2.2.31 | physiological function |
the enzyme is not involved in the aberrant DNA repair of UV-induced DNA damage |
751796 |
3.2.2.31 | physiological function |
the enzyme plays a significant role in oxidative DNA damage repair in vivo |
744766 |
3.2.2.31 | physiological function |
the enzyme plays an important role in preventing 7,8-dihydro-8-oxo-2'-deoxyguanosine-associated mutations by removing adenines misincorporated opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine lesions during DNA replication |
744300 |
3.2.2.31 | physiological function |
the enzyme plays an important role in the prevention of DNA mutations caused by the oxidatively damaged lesion 7,8-dihydro-8-oxo-2'-deoxyguanosine by removal of misincorporated adenine residues in 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mismatched base pairs using N-glycosylase activity |
744299 |
3.2.2.31 | physiological function |
the enzyme plays an important role in the prevention of DNA mutations resulting from the presence of the oxidatively damaged lesion 7,8-dihydro-8-oxo-2'-deoxyguanosine in DNA by the removal of misincorporated adenine residues in 7,8-dihydro-8-oxo-2'-deoxyguanosine:adenine mispairs and also exhibits adenine glycosylase activity toward adenine in guanine:adenine and cytosine:adenine mismatches |
744292 |
3.2.2.31 | physiological function |
the enzyme prevents DNA mutations caused by the misincorporation of adenine opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine by catalyzing the deglycosylation of the aberrant adenine |
744297 |
3.2.2.31 | physiological function |
the enzyme prevents mutations due to misincorporation of adenine opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine during DNA replication by removing the adenine base |
744293 |