EC Number |
General Information |
Reference |
---|
3.2.1.63 | evolution |
the enzyme belongs to the glycosyl hydrolase family 29, GH29, of retaining fucosidases |
732150, 732382 |
3.2.1.63 | metabolism |
the enzyme is involved in the degradation of intestinal fucosyl glycans by Clostridium perfringens ATCC 13124 |
750985 |
3.2.1.63 | more |
the enzyme shows active-site conformational flexibility, structure-function analysis, overview |
732150 |
3.2.1.63 | more |
the side chain amide group of the asparagine residue, N423, is proposed to act as the general base to activate this water nucleophile, with assistance provided by a nearby D766. In the crystal structure, the D766 is hydrogen bonds with the N423 |
732382 |
3.2.1.63 | physiological function |
AfcA plays essential role in degrading alpha1,2-fucosylated milk oligosaccharides and also glycoconjugates, in the gastrointestinal tracts of the host |
708607 |
3.2.1.63 | physiological function |
the enzyme contributes to the virulence of Tannerella forsythia |
-, 752322 |