EC Number |
General Information |
Reference |
---|
3.2.1.180 | evolution |
the enzyme is a member of the glycoside hydrolase family 88, GH88 |
754479 |
3.2.1.180 | metabolism |
the enzyme is involved in the metabolic pathway for degradation of glycosaminoglycans |
731656 |
3.2.1.180 | more |
a hydration-initiated mechanism with a transition state with positive charge at carbon 5 and the endocyclic oxygen is proposed, transition-state structure for the first irreversible step of this mechanism, overview |
731656 |
3.2.1.180 | more |
glycosaminoglycan degradation mechanism, combined quantum mechanical and molecular mechanical method and simulation, modelling, two pathways, detailed overview. Almost all interactions between the substrate and enzyme are related to the D-glucuronic acid unit, whereas no recognition specificity is observed for the N-acetyl-D-galactosamine unit |
754479 |
3.2.1.180 | physiological function |
unsaturated glucuronyl hydrolases acts on the unsaturated uronic-acid-containing oligosaccharides to remove the unusual non-reducing terminal monomer units |
731656 |