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EC Number	General Information	Commentary	Reference
3.2.1.169	malfunction	enzyme knockout mice show nearly complete perinatal lethality associated with low circulating glucose and low liver glycogen stores. Enzyme loss leads to defects in metabolic homeostasis culminating in obesity and insulin resistance	751058
3.2.1.169	malfunction	enzyme loss in Drosophila globally impacts the epigenetic machinery allowing N-acetyl-D-glucosamine accumulation on RNA polymerase II and numerous chromatin factors including TRX, ASH1, and SET1	751087
3.2.1.169	metabolism	caspase-3 efficiently cleaved O-GlcNAcase	704403

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Release 2023.1 (January 2023)