Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search General Information

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 10 of 64 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.143evolution canonical poly(ADP-ribose) glycohydrolase is a highly conserved protein found in organisms ranging from protozoa to humans, phylogenetic analysis. The full-length enzyme from Tetrahymena thermophila is highly similar to the minimal catalytic region of thhe human enzyme, but it lacks the obvious RS/MTS motif 732568
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.143evolution conservation of key residues involved in the catalytic process 732734
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.143evolution conservation of overall fold amongst mammalian enzyme glycohydrolase domains, additional flexible regions in the catalytic site, overview 732714
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.143evolution full-length ARH3 (ARH3FL) adopts a compact all-alpha-helical fold with a central deep ADPR-binding cleft, a signature of the ARH3 superfamily 754165
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.143evolution function and domain architecture of human ADP-ribosylation removing enzymes, overview. The key poly(ADP-ribose) (PAR) processing enzyme, PARG, emerged only recently 754710
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.143malfunction a deficiency in PARG glycohydrolase activity prolongs DNA damage foci, containing PAR, and similarly delays DNA repair, causing hypersensitivity to DNA damaging agents and selective killing of repair-deficient tumors such as BRCA mutated breast cancers-deficient cancer cells in a manner similar to PARP inhibition 754122
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.143malfunction benzo(a)pyrene induces the cell cycle in enzyme-suppressed shPARG cells, phenotype, overview 731761
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.143malfunction disruption of DrPARG expression causes accumulation of endogenous poly-ADP-ribose (PAR) and compromises recovery from UV radiation damage. Endogenous PAR levels in Deinococcus radiodurans are elevated after UV irradiation, indicating that the prokaryotic PARylation may be involved in resistance to genotoxic stresses -, 754824
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.143malfunction enzyme deficiency leads to cell death whilst enzyme depletion causes sensitisation to certain DNA damaging agents 732714
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.143malfunction genetic disruption of the enzyme leads to increased level of cell death by accumulation of poly(ADP-ribose) 731453
Results 1 - 10 of 64 > >>