EC Number   |
General Information |
Reference |
|---|
   3.2.1.113 | malfunction |
aberrant regulation of alpha-1,2 mannosidases can result in cancer. MAN1C1 plays a role in tumor suppression in hepatocarcinogenesis. Down-regulation of MAN1C activates unfolded protein response during hepatocarcinogenesis |
750718 |
| 3.2.1.113 | malfunction |
aberrant regulation of alpha-1,2 mannosidases can result in cancer. Upregulation of MAN1A1 activates unfolded protein response during hepatocarcinogenesis |
750718 |
| 3.2.1.113 | malfunction |
abolishment of two functionally redundant mannosidases, MNS1 and MNS2, responsible for alpha-1,2-mannose trimming on the A and C branches of plant N-glycans lead to severe root growth inhibition under salt stress conditions in Arabidopsis |
751608 |
| 3.2.1.113 | malfunction |
blocking alpha-1,2-mannosidase in regulatory T cells results in the migration of significantly lower numbers to the peripheral lymph nodes in skin grafted mice following adoptive transfer |
706455 |
| 3.2.1.113 | malfunction |
in triple KO (MAN1A1, MAN1A2, and MAN1B1) cells, Man9GlcNAc2 and Man8GlcNAc2 are the major N-glycan structures. Knockout of the MAN1A1 or MAN1A2 gene does not change the glycan profiles. Double KO cells (MAN1A1, MAN1A2) displayed increased high-mannose-type and decreased complex-type glycans. The N-glycan structures on recombinant proteins expressed in triple KO cells are simplified and changed from complex types to high-mannose types at the protein level |
751118 |
| 3.2.1.113 | metabolism |
overexpression MAN1C1 shows anti-tumor effect by inducing apoptosis. MAN1C1 overexpression remarkably increases the ratio of Bax/Bcl-2 and inhibits epithelial-mesenchymal transition by increasing the expression of E-CA. In addition, the ratio of Bax/Bcl-2 and E-cadherin is increased in MAN1C1 gene overexpression renal cancer cells compared with the control cells |
751168 |
| 3.2.1.113 | metabolism |
part of N-glycan pathway |
704576 |
| 3.2.1.113 | metabolism |
the enzyme catalyzes the first mannose trimming step in the processing of mammalian Asn-linked oligosaccharides |
754053 |
| 3.2.1.113 | metabolism |
the enzyme is involved in the processing of N-linked mannans |
-, 754617 |
| 3.2.1.113 | physiological function |
alpha-1,2-mannosidase function is not required for the suppressive capacity of regulatory T cells in vitro, but influences regulatory T cell adherence in vitro andmigration in vivo |
706455 |
