EC Number   |
General Information |
Reference |
|---|
   3.1.3.43 | metabolism |
the enzyme is involved in the regulation of pyruvate dehydrogenase performing its activating dephosphorylation, together with phosphorylation and inactivation by pyruvate dehydrogenase kinase, PDK. Pyruvate dehydrogenase phosphatase PDP1 activity and expression is positively correlated with citrate synthase activity, regulation, overview |
715323 |
| 3.1.3.43 | physiological function |
allosteric activation of pyruvate dehydrogenase phosphatase and protein phosphatase 2Calpha leads to insulin-mimetic and insulin-sensitizing effects |
714447 |
| 3.1.3.43 | physiological function |
forced expression of pyruvate dehydrogenase phosphatase catalytic subunit PDP2 in CD4+ cells reduces the in vitro Th17 T-cell differentiation, whereas shRNA-based suppression of PDP2 expression increases in vitro Th17 differentiation and augments experimental autoimmune encephalomyelitis |
752060 |
| 3.1.3.43 | physiological function |
glycolysis and lactate production in in vitro Th17-polarized T-cells is reduced and the expression of pyruvate dehydrogenase phosphatase catalytic subunit and Pdh enzyme activity are increased in Th17 cells from animals deficient for inducible cAMP early repressor/cAMP response element modulator ICER/CREM. ICER binds to the Pdp2 promoter and suppresses its expression |
752060 |
| 3.1.3.43 | physiological function |
in embryonic stem cells, Pdp1 expression is 27fold decreased on differentiation day 8 compared to differentiation day 0, accompanied by suppressed mitochondrial indices, including ATP levels, membrane potential, reactive oxygen species and mitochondrial Ca2+. Pdp1 overexpression significantly enhances the mitochondrial indices and pyruvate dehydrogenase activity and reduces the expression of cardiac differentiation marker mRNA and the cardiac differentiation rate. A knockdown of the Pdp1 gene promotes the expression of cardiac differentiation marker mRNA and the cardiac differentiation rate |
750487 |
| 3.1.3.43 | physiological function |
overexpression of small RNA miR-195 results in enhanced apoptosis, decreased mitochondrial membrane potential and cellular ATP content upon hydrogen peroxide stimulation. The effects can be partially rescued by PDPR or flavin adenine dinucleotide-dependent oxidoreductase domain containing protein FOXRED1. In preeclamptic patients, lowered circulating levels of miR-195 are found at early-to-mid gestation and term pregnancy, and marked increases in FOXRED1 and PDPR expression are observed in the placenta when compared with gestational week-matched controls |
751248 |
| 3.1.3.43 | physiological function |
Ptc6 interacts with pyruvate dehydrogenase complex E1alpha subunit Pda1. A Ptc6 deletion mutant exhibits a marked increase in Pda1 S313 phosphorylation |
751092 |
