EC Number   |
General Information |
Reference |
|---|
   3.1.22.1 | malfunction |
loss of all three DNase II genes (nuc-1, crn-6 or crn-7) does not affect the activation or progression of cell death. Removal or disruption of NUC-1 secretion signal eliminates NUC-1's ability to mediate DNA degradation across its expression border |
-, 710378 |
| 3.1.22.1 | malfunction |
loss of CRN-7 leads to up-regulation of antimicrobial genes |
749843 |
| 3.1.22.1 | malfunction |
loss of NUC-1 leads to up-regulation of antimicrobial genes |
749843 |
| 3.1.22.1 | physiological function |
deoxyribonuclease II has a major role in cellular DNA degradation |
751444 |
| 3.1.22.1 | physiological function |
DNase II gene shows relatively low genetic diversity with regard to the non-synonymous single nucleotide polymorphisms, suggesting that the enzyme has been well conserved |
708175 |
| 3.1.22.1 | physiological function |
fundamental role in the degradation of DNA from both apoptotic cells, and nuclei extruded from red blood cells during erythropoiesis; mice lacking DNase II die late in embryogenesis |
714896 |
| 3.1.22.1 | physiological function |
key role of DNase II in DNA sensing by the DNA sensor Toll-like receptor 9 (TLR9). DNase II is required for TLR9 activation by bacterial genomic DNA. TLR9 responds to DNA fragments generated by DNase II |
751649 |
| 3.1.22.1 | physiological function |
main DNase of the stratum corneum |
716699 |
| 3.1.22.1 | physiological function |
NUC-1 is the major DNase II for degrading apoptotic DNA |
742126 |
| 3.1.22.1 | physiological function |
the enzyme induces early humoral immune responses in infected mice. It may play an important role in the host-parasite interaction |
750197 |
