EC Number   |
General Information |
Reference |
|---|
   3.1.11.1 | evolution |
exonuclease 1 is highly conserved from yeast to human |
716779 |
| 3.1.11.1 | evolution |
the enzyme is a member of the RAD2 nuclease family |
730495 |
| 3.1.11.1 | malfunction |
a defect of the enzyme is associated with different types of cancers, including Lynch Syndrome, breast, ovarian, lung, pancreatic, and gastric tract cancer |
750877 |
| 3.1.11.1 | malfunction |
enzyme mutations correlate with increased susceptibility to some cancers |
750362 |
| 3.1.11.1 | malfunction |
enzyme-deficient exo1DELTA yeast cells repairing plasmids with 5'-extensions can produce repair junction with templated insertions. Exo1D mutants have a reduced median size of deletions when joining DNA with blunt ends, and exo1D pol4D mutants repair blunt ends with a very low frequency of deletions, phenotypes, overview |
-, 716398 |
| 3.1.11.1 | malfunction |
in nonreplicating cells, depletion or downregulation of hEXO1 reduces unscheduled DNA synthesis after UV irradiation, prevents ubiquitylation of histone H2A, and impairs activation of the checkpoint signal transduction cascade in response to UV damage |
716779 |
| 3.1.11.1 | malfunction |
nearly all double-strand breaks are converted to chromosome breaks in cells lacking both exonuclease 1 activity and RAD50/MRE11/XRS2, MRX, complex |
714806 |
| 3.1.11.1 | malfunction |
on exposure to camptothecin, depletion of EXO1 in CtIP-deficient cells increases the frequency of DNA-PK-dependent radial chromosome formation |
714833 |
| 3.1.11.1 | metabolism |
exonuclease 1 is a multifunctional 5'->3' exonuclease and a DNA structure-specific DNA endonuclease |
750362 |
| 3.1.11.1 | more |
comparison of exonuclease 1, EXO1, and Flap endonuclease 1, FEN1, activities on G4 DNA substrates, hFEN1, but not hEXO1, cleaves 59 telomeric G4 DNA, overview. Telomeres are composed of G-rich repeats that readily form G4 DNA. human EXO1 and FEN1 exhibit distinct activities on G4 DNA substrates representative of intermediates in immunoglobulin class switch recombination, distinct telomeric phenotypes caused by EXO1 and FEN1 deficiencies, overview |
716689 |
