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EC Number	General Information	Commentary	Reference
2.7.9.2	metabolism	formation of phosphoenolpyruvate is an initial step in gluconeogenesis	737626
2.7.9.2	metabolism	gluconeogenic enzyme	745202
2.7.9.2	metabolism	phosphoenolpyruvate produced by the enzyme is required in the shikimate biosynthesis, pathway overview. The expression levels of the enzyme transketolase I (encoded by tktA) and phosphoenolpyruvate synthase (encoded by ppsA) have a critical impact on the phosphoenolpyruvate and erythrose-4-phosphate availability, which are important determinants for in vivo 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase activity	737850
2.7.9.2	metabolism	the enzyme that may be responsible for the production of ATP from AMP formed by ADP-dependent glucokinase and phosphofructokinase reactions in the modified Embden-Meyerhof pathway of Pyrococcus furiosus	744138
2.7.9.2	physiological function	the enzyme is essential for growth of Escherichia coli on 3-carbon sources such as pyruvate. The production of phosphoenolpyruvate synthase has also been linked to bacterial virulence and antibiotic resistance	737626

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Release 2023.1 (January 2023)