EC Number   |
General Information |
Reference |
|---|
   2.7.7.B22 | evolution |
enzyme Hermes is a member of the hAT transposon superfamily, which has active representatives, including McClintock's archetypal Ac mobile genetic element, in many eukaryotic species |
738023 |
| 2.7.7.B22 | evolution |
IS1634-1 or gene APM_2825 in the sequenced 2007 culture might be a recent insertion in the chromosome |
739660 |
| 2.7.7.B22 | evolution |
protein coevolutionary information can be used to classify groups of physically connected, coevolving residues into elements called sectors, which are useful for understanding the folding, allosteric interactions, and enzymatic activity of proteins. Sleeping Beauty transposase contains two sectors, which span across conserved domains, and are enriched in DNA-binding residues, indicating that the DNA binding and endonuclease functions of the transposase coevolve. Sector residues are highly sensitive to mutations, and most mutations of these residues strongly reduce transposition rate. Mutations with a strong effect on free energy of folding in the DDE domain of the transposase significantly reduce transposition rate. Mutations that influence DNA and protein-protein interactions generally reduce transposition rate, although most hyperactive mutants are also located on the protein surface, including residues with protein-protein interactions. Hyperactivity results from the modification of protein interactions, rather than the stabilization of protein fold. Mutations in sector, conserved and core residues usually have a destabilizing effect on the structure, effects of mutations on folding energies, and effect of protein-protein and protein-DNA interactions on transposition rate, overview |
739123 |
| 2.7.7.B22 | evolution |
Sleeping Beauty is a member of the mariner family of DNA transposons |
739500 |
| 2.7.7.B22 | evolution |
Sleeping Beauty is a prominent Tc1/mariner superfamily DNA transposon, mobilized by a transposase enzyme that catalyses DNA cleavage and integration at short specific sequences at the transposon ends |
739149 |
| 2.7.7.B22 | evolution |
Tgf2 belongs to the hAT superfamily of transposons, Carassius auratus Tgf2 transposon is another autonomously active vertebrate hAT transposon |
739693 |
| 2.7.7.B22 | evolution |
the enzyme belongs to the family of hAT transposases |
739041 |
| 2.7.7.B22 | evolution |
the enzyme belongs to the IS711 transposases |
-, 739746 |
| 2.7.7.B22 | evolution |
the enzyme Galileo is a members of the P-element superfamily. In contrast to other members of the P-element superfamily, it has unusually long terminal inverted-repeats (TIRs) that resemble those of Foldback elements. Different subfamilies of Galileo exist, known as DbuzGalileo-K and DbuzGalileo-N,while DbuzGalileo-G denotes the subfamily of the synthetic element. The various Galileo subfamilies have TIRs of different lengths, but share significant sequence homologies at the tips of the elements where one might expect the transposase to bind. Comparison of THAP domain protein sequences and cross-reactivity between the subfamilies, overview |
738320 |
| 2.7.7.B22 | evolution |
the enzyme is a member of the IS1634 family |
-, 739660 |
